마우스 공간지각과 기억 형성에 미치는 전정 유래 정보의 규명
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한규철 | - |
dc.contributor.author | 김민범 | - |
dc.contributor.author | 김미주 | - |
dc.date.available | 2020-02-27T13:41:27Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2092-8882 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4519 | - |
dc.description.abstract | Objectives: We aimed to study the role of vestibular input on spatial memory performance in mice that had undergone bilateral surgical labyrinthectomy, semicircular canal (SCC) occlusion and 4G hypergravity exposure. Methods: Twelve to 16 weeks old ICR mice (n=30) were used for the experiment. The experimental group divided into 3 groups. One group had undergone bilateral chemical labyrinthectomy, and the other group had performed SCC occlusion surgery, and the last group was exposed to 4G hypergravity for 2 weeks. The movement of mice was recorded using camera in Y maze which had 3 radial arms (35 cm long, 7 cm high, 10 cm wide). We counted the number of visiting arms and analyzed the information of arm selection using program we developed before and after procedure. Results: The bilateral labyrinthectomy group which semicircular canal and otolithic function was impaired showed low behavioral performance and spacial memory. The semicircular canal occlusion with CO2 laser group which only semicircular canal function was impaired showed no difference in performance activity and spatial memory. However the hypergravity exposure group in which only otolithic function impaired showed spatial memory function was affected but the behavioral performance was spared. The impairment of spatial memory recovered after a few days after exposure in hypergravity group.Conclusions: This spatial memory function was affected by bilateral vestibular loss. Space-related information processing seems to be determined by otolithic organ information rather than semicircular canals. Due to otolithic function impairment, spatial learning was impaired after exposure to gravity changes in animals and this impaired performance was compensated after normal gravity exposure. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한평형의학회 | - |
dc.relation.isPartOf | Research in Vestibular Science | - |
dc.title | 마우스 공간지각과 기억 형성에 미치는 전정 유래 정보의 규명 | - |
dc.title.alternative | Identification of Vestibular Organ Originated Information on Spatial Memory in Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.21790/rvs.2018.17.4.134 | - |
dc.identifier.bibliographicCitation | Research in Vestibular Science, v.17, no.4, pp.134 - 141 | - |
dc.identifier.kciid | ART002414106 | - |
dc.citation.endPage | 141 | - |
dc.citation.startPage | 134 | - |
dc.citation.title | Research in Vestibular Science | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 한규철 | - |
dc.subject.keywordAuthor | 고중력 | - |
dc.subject.keywordAuthor | 공간지각 | - |
dc.subject.keywordAuthor | 마우스 | - |
dc.subject.keywordAuthor | 전정병변 | - |
dc.subject.keywordAuthor | 행동 | - |
dc.subject.keywordAuthor | Hypergravity | - |
dc.subject.keywordAuthor | Spatial learning | - |
dc.subject.keywordAuthor | Mouse | - |
dc.subject.keywordAuthor | Vestibular lesion | - |
dc.subject.keywordAuthor | Behavior | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.