만성 저온 스트레스 동물모델에서의 黃連의 항염증 효능 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최진규 | - |
dc.contributor.author | 허유진 | - |
dc.contributor.author | 이원일 | - |
dc.contributor.author | 김윤경 | - |
dc.contributor.author | 이태희 | - |
dc.contributor.author | 오명숙 | - |
dc.date.available | 2020-02-27T13:42:33Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4637 | - |
dc.description.abstract | Objectives : The aim of this study was to investigate whether the extract of Coptidis Rhizoma inhibits inflammation in chronic cold stress (CCS)-exposed mice or not. Methods : Coptidis Rhizoma extract (CRE) was made by reflux with distilled water. Male ICR mice (7 weeks old) were divided randomly into 5 groups: (1) control, (2) CCS, (3) CCS+CRE 100 ㎎/㎏, (4) CCS+CRE 300 ㎎/㎏, (5) CCS+CRE 1,000 ㎎/㎏ groups. Mice were orally administered once a day for 14 days starting from 1 day before CCS. Group (2)-(5) were exposed to CCS conditions that maintained at 4℃ for 2 h once a day for 14 days. The levels of serum cortisol and hypothalamic prostaglandin E1 (PGE1) and PGE2 were measured by enzyme-linked immunosorbent assay kit. The expression levels of several pro-inflammatory factors like heat shock protein 70 (HSP70), c-fos, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) were measured by western blot analysis in mouse hypothalamus. Results : Oral administration of CRE 1,000 ㎎/㎏ significantly suppressed the increase of serum cortisol levels in mice exposed to CCS. CCS-exposed mice had significantly increased the expression of HSP70, c-fos, and NF-kB in hypothalamus, while CRE treatment significantly attenuated the elevation of these pro-inflammatory factors. The ratio of PGE2/PGE1 was also higher in CCS-exposed mice than control group. CRE treatment significantly reduced the increase of PGE2/PGE1 ratio induced by CCS. Conclusion : These findings suggest that Coptidis Rhizoma may work as a potential agent to modulate inflammatory responses under the condition of cold adaptation formed by CCS. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 만성 저온 스트레스 동물모델에서의 黃連의 항염증 효능 연구 | - |
dc.title.alternative | Anti-inflammatory effects of Coptidis Rhizoma in chronic cold stress-exposed mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.6116/kjh.2018.33.6.35 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.33, no.6, pp.35 - 42 | - |
dc.identifier.kciid | ART002409368 | - |
dc.citation.endPage | 42 | - |
dc.citation.startPage | 35 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.subject.keywordAuthor | Coptidis Rhizoma | - |
dc.subject.keywordAuthor | chronic cold stress | - |
dc.subject.keywordAuthor | inflammation | - |
dc.description.journalRegisteredClass | kci | - |
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