梔子의 Apoptosis유발 억제효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한영수 | - |
dc.contributor.author | 이태희 | - |
dc.contributor.author | 김연섭 | - |
dc.date.available | 2020-02-27T14:41:54Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1229-1218 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4840 | - |
dc.description.abstract | Objectives : The purpose of this study was to observe the effects of Gardeniae Fructus on 4-HNE-induced apoptosis in PC-12 cell. Methods : A MTT assay was conducted to observe the cytotoxicity of Gardeniae Fructus on the PC-12 cell viability and the cytoprotective effects of Gardeniae Fructus on PC-12 cell against oxidative stress caused by 4-HNE. And western blot was conducted to observe the expression of Bax, Bcl-2, Caspase-3, TNF-α proteins which are involved in intrinsic and extrinsic apoptosis pathway. Results : 25, 50, 100, 200 and 400 ㎍/㎖ of Gardeniae Fructus water extract had no cytotoxicity on PC-12 cell. 200 ㎍/㎖ of Gardeniae Fructus water extract had significant cytoprotective effect on PC-12 cell against oxidative stress caused by 4-HNE. The expression of Bax protein in 50, 100 and 200 ㎍/㎖ of Gardeniae Fructus was significantly decreased in PC-12 cell. The expression of Bcl-2 protein in 200 ㎍/㎖ of Gardeniae Fructus was significantly increased in PC-12 cell. The expression of Caspase-3 protein in 100 and 200 ㎍/㎖ of Gardeniae Fructus was significantly decreased in PC-12 cell. The expression of TNF-α protein in 50 ㎍/㎖ of Gardeniae Fructus was significantly decreased in PC-12 cell. Conclusions : These results suggest that Gardeniae Fructus water extract is effective to protect PC-12 cell from 4-HNE induced apoptosis. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한의학방제학회 | - |
dc.relation.isPartOf | 대한한의학 방제학회지 | - |
dc.title | 梔子의 Apoptosis유발 억제효과 | - |
dc.title.alternative | Inhibitory Effects of Gardeniae Fructus on Apoptosis induced by 4-HNE in PC-12 Cell | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.14374/HFS.2018.26.3.195 | - |
dc.identifier.bibliographicCitation | 대한한의학 방제학회지, v.26, no.3, pp.195 - 205 | - |
dc.identifier.kciid | ART002379516 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 205 | - |
dc.citation.startPage | 195 | - |
dc.citation.title | 대한한의학 방제학회지 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 한영수 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.contributor.affiliatedAuthor | 김연섭 | - |
dc.subject.keywordAuthor | Gardeniae Fructus | - |
dc.subject.keywordAuthor | 4-HNE | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | Caspase-3 | - |
dc.subject.keywordAuthor | TNF-α | - |
dc.description.journalRegisteredClass | kci | - |
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