Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm
DC Field | Value | Language |
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dc.contributor.author | 김용범 | - |
dc.contributor.author | 최재문 | - |
dc.contributor.author | 장영진 | - |
dc.contributor.author | 최혜란 | - |
dc.contributor.author | 인준용 | - |
dc.contributor.author | 양홍석 | - |
dc.date.available | 2020-06-12T00:35:24Z | - |
dc.date.created | 2020-06-03 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/52263 | - |
dc.description.abstract | Background: In this study, we used an ex-vivo model to investigate the recovery pattern of both the train-of-four (TOF) ratio and first twitch tension of TOF (T1), and determined their relationship during recovery from rocuronium-induced neuromuscular blockade at various concentrations of sugammadex. Methods: Tissue specimens of the phrenic nerve-hemidiaphragm were obtained from 60 adult Sprague-Dawley rats. Each specimen was immersed in an organ bath filled with Krebs buffer solution and stimulated with the TOF pattern using indirect supramaximal stimulation at 20-second intervals. After a 30-minute stabilization period, rocuronium loading and booster doses were serially administered at 10-minute intervals in each sample until > 95% depression of T1 was confirmed. Specimens were randomly allocated to either the control group (washout) or to one of five sugammadex concentration groups (0.75, 1, 2, 4, or 8 times equimolar doses of rocuronium to produce > 95% T1 depressions; SGX0.75, SGX1, SGX2, SGX4, and SGX8, respectively). Recovery from neuromuscular blockade was monitored using T1 and the TOF ratio simultaneously until the recovery of T1 to > 95% and the TOF ratio to > 0.9. Results: Statistically significant intergroup differences were observed between the recovery patterns of T1 and the TOF ratio (TOFR, P < 0.050), except between SGX2 and SGX4 groups. TOFR/T1 values were maintained at nearly 1 in the control, SGX0.75, and SGX1 groups; however, they were exponentially decayed in the SGX2, SGX4, and SGX8 groups. Conclusions: Recovery of the TOF ratio may be influenced by the sugammadex dose, and a TOF ratio of 1.0 may be achieved before full T1 recovery if administration of sugammadex exceeds that of rocuronium. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한마취통증의학회 | - |
dc.relation.isPartOf | Korean Journal of Anesthesiology | - |
dc.title | Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm | - |
dc.title.alternative | 랫드 횡격막신경 편측횡격막에서 로쿠로늄 유도 신경근 차단 중 사연속자극비 회복 진행에 대한 다양한 슈가마덱스 용량의 영향 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000538020500009 | - |
dc.identifier.doi | 10.4097/kja.19278 | - |
dc.identifier.bibliographicCitation | Korean Journal of Anesthesiology, v.73, no.3, pp.239 - 246 | - |
dc.identifier.kciid | ART002591555 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85085881515 | - |
dc.citation.endPage | 246 | - |
dc.citation.startPage | 239 | - |
dc.citation.title | Korean Journal of Anesthesiology | - |
dc.citation.volume | 73 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 김용범 | - |
dc.contributor.affiliatedAuthor | 장영진 | - |
dc.subject.keywordAuthor | Acetylcholine | - |
dc.subject.keywordAuthor | Neuromuscular blockade | - |
dc.subject.keywordAuthor | Neuromuscular blocking agent | - |
dc.subject.keywordAuthor | Neuromuscular physiology | - |
dc.subject.keywordAuthor | Rocuronium | - |
dc.subject.keywordAuthor | Sugammadex. | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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