Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via alpha 2-Adrenoceptors in Trigeminal Ganglion Neurons
DC Field | Value | Language |
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dc.contributor.author | Im, Sang-Taek | - |
dc.contributor.author | Jo, Youn Yi | - |
dc.contributor.author | Han, Gayoung | - |
dc.contributor.author | Jo, Hyun Jung | - |
dc.contributor.author | Kim, Yong Ho | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.date.available | 2020-02-27T15:43:32Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5264 | - |
dc.description.abstract | Dexmedetomidine, an alpha 2-adrenoceptor agonist, is widely used as a sedative and analgesic agent in a number of clinical applications. However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system. Two types of voltage-gated sodium channels, Na v 1.7 and Na v 1.8, as well as alpha 2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG). Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (I-Na) via alpha 2-adrenoceptors in dissociated, small-sized TG neurons. Dexmedetomidine caused a concentration-dependent inhibition of I-Na in small-sized TG neurons. I-Na inhibition by dexmedetomidine was blocked by yohimbine, a competitive alpha 2-adrenoceptor antagonist. Dexmedetomidine-induced inhibition of I-Na was mediated by G protein-coupled receptors (GPCRs) as this effect was blocked by intracellular perfusion with the G protein inhibitor GDP beta-S. Our results suggest that the I-Na inhibition in small-sized TG neurons, mediated by the activation of Gi/o protein-coupled alpha 2-adrenoceptors, might contribute to the analgesic effects of dexmedetomidine in the trigeminal system. Therefore, these new findings highlight a potential novel target for analgesic drugs in the orofacial region. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | MEDIATORS OF INFLAMMATION | - |
dc.subject | RAT DORSAL-ROOT | - |
dc.subject | SPINAL-CORD | - |
dc.subject | NEUROPATHIC PAIN | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | CURRENTS | - |
dc.subject | ACETYLCHOLINE | - |
dc.subject | HYPERALGESIA | - |
dc.subject | NOCICEPTORS | - |
dc.subject | COMBINATION | - |
dc.subject | SUBTYPES | - |
dc.title | Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via alpha 2-Adrenoceptors in Trigeminal Ganglion Neurons | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000444878100001 | - |
dc.identifier.doi | 10.1155/2018/1782719 | - |
dc.identifier.bibliographicCitation | MEDIATORS OF INFLAMMATION | - |
dc.identifier.scopusid | 2-s2.0-85059391825 | - |
dc.citation.title | MEDIATORS OF INFLAMMATION | - |
dc.contributor.affiliatedAuthor | Im, Sang-Taek | - |
dc.contributor.affiliatedAuthor | Jo, Youn Yi | - |
dc.contributor.affiliatedAuthor | Jo, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Yong Ho | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kyu | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RAT DORSAL-ROOT | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | CURRENTS | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | NOCICEPTORS | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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