Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells
DC Field | Value | Language |
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dc.contributor.author | Cha, Seon-Heui | - |
dc.contributor.author | Kim, Hyun-Soo | - |
dc.contributor.author | Hwang, Yongha | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-02-27T15:43:41Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5278 | - |
dc.description.abstract | Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of beta-cells. Using a transgenic zebrafish, we screened similar to 50 seaweed crude extracts to identify materials that protect beta-cells from free fatty acid damage. We found that an extract of the red seaweed Polysiphonia japonica (PJE) had a beta-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in beta-cells. PJE was found to preserve cell viability and glucose-induced insulin secretion in a pancreatic beta-cell line, Ins-1, treated with palmitate. Additionally, PJE prevented palmitate-induced insulin secretion dysfunction in zebrafish embryos and mouse primary islets and improved insulin secretion in beta-cells against palmitate treatment. These findings suggest that PJE protects pancreatic beta-cells from palmitate-induced damage. PJE may be a potential therapeutic functional food for diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | - |
dc.title | Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000449793900001 | - |
dc.identifier.doi | 10.1155/2018/4973851 | - |
dc.identifier.bibliographicCitation | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v.2018 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85060937644 | - |
dc.citation.title | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | - |
dc.citation.volume | 2018 | - |
dc.contributor.affiliatedAuthor | Cha, Seon-Heui | - |
dc.contributor.affiliatedAuthor | Hwang, Yongha | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | FREE FATTY-ACIDS | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | RED ALGA | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITIES | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | MARINE-ALGAE | - |
dc.subject.keywordPlus | INS-1 CELLS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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