Urinary and Blood MicroRNA-126 and-770 are Potential Noninvasive Biomarker Candidates for Diabetic Nephropathy: a Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Sungjin | - |
dc.contributor.author | Moon, SeongRyeol | - |
dc.contributor.author | Lee, Kiyoung | - |
dc.contributor.author | Park, Ie Byung | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Nam, Seungyoon | - |
dc.date.available | 2020-02-27T15:44:09Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5323 | - |
dc.description.abstract | Background/Aims: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical and clinical studies. This meta-analysis aims to identify significant blood- and urine-incident microRNAs as diagnostic/prognostic biomarker candidates for DN. Methods: PubMed, Web of Science, and Cochrane Library were searched from their earliest records through 12th Dec 2016. Relevant publications for the meta analysis included (1) human participants; (2) microRNAs in blood and urine; (3) DN studies; and (4) English language. Four reviewers, including two physicians, independently and blindly extracted published data regarding microRNA profiles in blood and/or urine from subjects with diabetic nephropathy. A random-effect model was used to pool the data. Statistical associations between diabetic nephropathy and urinary or blood microRNA expression levels were assessed. Results: Fourteen out of 327 studies (n=2,747 patients) were selected. Blood or urinary microRNA expression data of diabetic nephropathy were pooled for this analysis. The hsa-miR-126 family was significantly (OR: 0.57; 95% CI: 0.44-0.74; p-value < 0.0001) downregulated in blood from patients with diabetic kidney disease, while its urinary level was upregulated (OR: 2931.12; 95% CI: 9.96-862623.21; p-value = 0.0059). The hsa-mi R-770 family microRNA were significantly (OR: 10.24; 95% CI: 2.37-44.25; p-value = 0.0018) upregulated in both blood and urine from patients with diabetic nephropathy. Conclusions: Our meta analysis suggests that hsa-miR-126 and hsa-miR-770 family microRNA may have important diagnostic and pathogenetic implications for DN, which warrants further systematic clinical studies. (C) 2018 The Author(s) Published by S Karger AG, Basel. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.relation.isPartOf | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | - |
dc.title | Urinary and Blood MicroRNA-126 and-770 are Potential Noninvasive Biomarker Candidates for Diabetic Nephropathy: a Meta-Analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000433152000003 | - |
dc.identifier.doi | 10.1159/000489148 | - |
dc.identifier.bibliographicCitation | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v.46, no.4, pp.1331 - 1340 | - |
dc.identifier.scopusid | 2-s2.0-85047736665 | - |
dc.citation.endPage | 1340 | - |
dc.citation.startPage | 1331 | - |
dc.citation.title | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Sungjin | - |
dc.contributor.affiliatedAuthor | Moon, SeongRyeol | - |
dc.contributor.affiliatedAuthor | Lee, Kiyoung | - |
dc.contributor.affiliatedAuthor | Park, Ie Byung | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.contributor.affiliatedAuthor | Nam, Seungyoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Diabetic nephropathy | - |
dc.subject.keywordAuthor | MicroRNAs | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordPlus | CIRCULATING MICRORNAS | - |
dc.subject.keywordPlus | ANGIOGENIC MICRORNAS | - |
dc.subject.keywordPlus | KIDNEY-DISEASE | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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