Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Yeon | - |
dc.contributor.author | Rho, Young-Soo | - |
dc.contributor.author | Choi, Eun-Chang | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.contributor.author | Woo, Joo-Hyun | - |
dc.contributor.author | Lee, Dong Hoon | - |
dc.contributor.author | Chung, Eun Jae | - |
dc.contributor.author | Park, Min Woo | - |
dc.contributor.author | Kim, Da-Hee | - |
dc.contributor.author | Joo, Young-Hoon | - |
dc.date.available | 2020-02-27T16:41:13Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12-29 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5362 | - |
dc.description.abstract | Background: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. Methods: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients. Seventy-two patients received postoperative radio(chemo) therapy. Results: Five-year disease-free survival (DFS) and disease-specific survival (DSS) rates were 38% and 45%, respectively. In univariate analysis, 5-year DFS was found to have significant and positive correlations with margin involvement (p < 0.001) and extracapsular spread (p = 0.025). Multivariate analysis confirmed that margin involvement (hazard ratio (HR): 2.81; 95% confidence interval (CI): 1.49-5.30; p = 0.001) and extracapsular spread (HR: 2.08; 95% CI: 1.08-3.99; p = 0.028) were significant factors associated with 5-year DFS. In univariate analysis, cervical lymph node metastasis (p = 0.048), lymphovascular invasion (p = 0.041), extracapsular spread (p = 0.015), and esophageal invasion (p = 0.033) were significant factors associated with 5-year DSS. In multivariate analysis, extracapsular spread (HR: 2.98; 95% CI: 1.39-6.42; p = 0.005) and esophageal invasion (HR: 2.87; 95% CI: 1.38-5.98; p = 0.005) remained significant factors associated with 5-year DSS. Conclusion: Margin involvement and extracapsular spread are factors influencing recurrence while extracapsular spread and esophageal invasion are factors affecting survival in patients with T4a hypopharyngeal cancer treated by primary surgery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.subject | SQUAMOUS-CELL CARCINOMA | - |
dc.subject | LARYNX PRESERVATION | - |
dc.subject | CERVICAL ESOPHAGUS | - |
dc.subject | NECK-CANCER | - |
dc.subject | HEAD | - |
dc.subject | INVASION | - |
dc.subject | MANAGEMENT | - |
dc.subject | RESECTION | - |
dc.subject | SURVIVAL | - |
dc.subject | PATTERNS | - |
dc.title | Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000419223900001 | - |
dc.identifier.doi | 10.1186/s12885-017-3880-6 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.17 | - |
dc.identifier.scopusid | 2-s2.0-85039697147 | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Woo, Joo-Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Head and neck neoplasms | - |
dc.subject.keywordAuthor | Hypopharynx | - |
dc.subject.keywordAuthor | Squamous cell carcinoma | - |
dc.subject.keywordAuthor | Surgery | - |
dc.subject.keywordAuthor | Treatment outcome | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | LARYNX PRESERVATION | - |
dc.subject.keywordPlus | CERVICAL ESOPHAGUS | - |
dc.subject.keywordPlus | NECK-CANCER | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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