Protective effect of casuarinin against glutamate-induced apoptosis in HT22 cells through inhibition of oxidative stress-mediated MAPK phosphorylation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ji Hoon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Choi, You-Kyung | - |
dc.date.available | 2020-02-27T16:41:21Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5374 | - |
dc.description.abstract | Glutamate is the major excitatory neurotransmitter in the central nervous system and is involved in oxidative stress during neurodegeneration. In the present study, casuarinin prevented glutamate-induced HT22 murine hippocampal neuronal cell death by inhibiting intracellular reactive oxygen species (ROS) production. Moreover, casuarinin reduced chromatin condensation and annexin-V-positive cell production induced by glutamate. We also confirmed the underlying protective mechanism of casuarinin against glutamate-induced neurotoxicity. Glutamate markedly increased the phosphorylation of extracellular signal regulated kinase (ERK)-1/2 and p38, which are crucial in oxidative stress-mediated neuronal cell death. Conversely, treatment with casuarinin diminished the phosphorylation of ERK1/2 and P38. In conclusion, the results of this study suggest that casuarinin, obtained from natural products, acts as potent neuroprotective agent by suppressing glutamate-mediated apoptosis through the inhibition of ROS production and activation of the mitogen activated protein kinase (MAPK) pathway. Thus, casuarinin can be a potential therapeutic agent in the treatment of neurodegenerative diseases. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | NEURONAL CELLS | - |
dc.subject | KINASE PATHWAYS | - |
dc.subject | CYCLE ARREST | - |
dc.subject | DEATH | - |
dc.subject | TOXICITY | - |
dc.subject | ACTIVATION | - |
dc.subject | CULTURES | - |
dc.subject | ERK1/2 | - |
dc.subject | LINE | - |
dc.subject | BARK | - |
dc.title | Protective effect of casuarinin against glutamate-induced apoptosis in HT22 cells through inhibition of oxidative stress-mediated MAPK phosphorylation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000415643400004 | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.10.075 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.23, pp.5109 - 5113 | - |
dc.identifier.scopusid | 2-s2.0-85033216241 | - |
dc.citation.endPage | 5113 | - |
dc.citation.startPage | 5109 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 27 | - |
dc.citation.number | 23 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Choi, You-Kyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Casuarinin | - |
dc.subject.keywordAuthor | Glutamate | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Mitogen-activated protein kinase | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | HT22 cells | - |
dc.subject.keywordPlus | NEURONAL CELLS | - |
dc.subject.keywordPlus | KINASE PATHWAYS | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CULTURES | - |
dc.subject.keywordPlus | ERK1/2 | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | BARK | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.