Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier
DC Field | Value | Language |
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dc.contributor.author | Fernandes-Cunha, Gabriella Maria | - |
dc.contributor.author | Na, Kyung-Sun | - |
dc.contributor.author | Putra, Ilham | - |
dc.contributor.author | Lee, Hyun Jong | - |
dc.contributor.author | Hull, Sarah | - |
dc.contributor.author | Cheng, Yu-Chia | - |
dc.contributor.author | Blanco, Ignacio Jesus | - |
dc.contributor.author | Eslani, Medi | - |
dc.contributor.author | Djalilian, Ali R. | - |
dc.contributor.author | Myung, David | - |
dc.date.available | 2020-06-16T04:35:44Z | - |
dc.date.created | 2020-06-16 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 2157-6564 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/53886 | - |
dc.description.abstract | Severe corneal injuries often result in permanent vision loss and remain a clinical challenge. Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their antiscarring, anti-inflammatory, and antiangiogeneic properties. We aimed to deliver lyophilized MSC secretome (MSC-S) within a viscoelastic gel composed of hyaluronic acid (HA) and chondroitin sulfate (CS) as a way to enhance corneal re-epithelialization and reduce complications after mechanical and chemical injuries of the cornea. We hypothesized that delivering MSC-S within HA/CS would have improved wound healing effects compared the with either MSC-S or HA/CS alone. The results showed that a once-daily application of MSC-S in HA/CS enhances epithelial cell proliferation and wound healing after injury to the cornea. It also reduced scar formation, neovascularization, and hemorrhage after alkaline corneal burns. We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA. The results from this study demonstrate a reproducible and efficient approach for delivering the MSC-S to the ocular surface for treatment of severe corneal injuries. Stem Cells Translational Medicine 2019;8:478-489 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | STEM CELLS TRANSLATIONAL MEDICINE | - |
dc.title | Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000465337000008 | - |
dc.identifier.doi | 10.1002/sctm.18-0178 | - |
dc.identifier.bibliographicCitation | STEM CELLS TRANSLATIONAL MEDICINE, v.8, no.5, pp.478 - 489 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85060138657 | - |
dc.citation.endPage | 489 | - |
dc.citation.startPage | 478 | - |
dc.citation.title | STEM CELLS TRANSLATIONAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Jong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cellular proliferation | - |
dc.subject.keywordAuthor | Chondroitin sulfate | - |
dc.subject.keywordAuthor | Cornea | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordPlus | ADHESION MOLECULE CD44 | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | OCULAR SURFACE | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | CHONDROITIN SULFATE | - |
dc.subject.keywordPlus | STEM/STROMAL CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSPARENCY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGE | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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