RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Suntaek | - |
dc.date.available | 2020-02-27T16:41:40Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5398 | - |
dc.description.abstract | After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis. To develop therapeutic strategies targeting RBPs, RNA interference-based oligonucleotides or small molecule inhibitors have been screened based on reduced RBP-RNA interaction and changed level of target RNAs. Identification of binding RNAs with high-throughput techniques and integral analysis of multiple datasets will help us develop new therapeutic drugs or prognostic biomarkers for human cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CANCER PREVENTION | - |
dc.relation.isPartOf | JOURNAL OF CANCER PREVENTION | - |
dc.title | RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.wosid | 000477003000001 | - |
dc.identifier.doi | 10.15430/JCP.2017.22.4.203 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER PREVENTION, v.22, no.4, pp.203 - 210 | - |
dc.identifier.kciid | ART002303238 | - |
dc.citation.endPage | 210 | - |
dc.citation.startPage | 203 | - |
dc.citation.title | JOURNAL OF CANCER PREVENTION | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Hong, Suntaek | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | RNA-binding proteins | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Chemoprevention | - |
dc.subject.keywordAuthor | Therapeutics | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.