Comprehensive evaluation of the revised international staging system in multiple myeloma patients treated with novel agents as a primary therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hyungwoo | - |
dc.contributor.author | Yoon, Dok Hyun | - |
dc.contributor.author | Lee, Jung Bok | - |
dc.contributor.author | Kim, Sung-Yong | - |
dc.contributor.author | Moon, Joon Ho | - |
dc.contributor.author | Do, Young Rok | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Lee, Ho Sup | - |
dc.contributor.author | Eom, Hyeon Seok | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.contributor.author | Min, Chang-Ki | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Jo, Jae-Cheol | - |
dc.contributor.author | Kang, Hye Jin | - |
dc.contributor.author | Mun, Yeung-Chul | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Lee, Je-Jung | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.contributor.author | Kim, Kihyun | - |
dc.date.available | 2020-02-27T16:41:47Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0361-8609 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5409 | - |
dc.description.abstract | The revised International Staging System (R-ISS) has recently been developed to improve the risk stratification of multiple myeloma (MM) patients over the ISS. We assessed the R-ISS in MM patients who were treated with novel agents as a primary therapy and evaluated its discriminative power and ability to reclassify patients from the ISS. A total of 514 newly diagnosed MM patients treated with novel agents including thalidomide, bortezomib, and lenalidomide as a primary therapy were included in this retrospective analysis. With a median follow-up duration of 42.3 months (range, 40.5-44.1), the median overall survival (OS) was 61.0 months. There was a significant difference in median OS (not reached, 60.9, and 50.1 months for stages 1, 2, and 3, respectively, P<0.001) among the three stages of R-ISS. The C-statistic was significantly greater for R-ISS than for ISS (0.769 vs. 0.696, P<0.001). The event NRI was -0.08 (95% confidence interval [CI], -0.18-0.01) and the non-event NRI was 0.05 (95% CI, -0.03-0.10), resulting in a total NRI of -0.03 (95% CI, -0.14-0.08, P=0.602). The R-ISS performs well and has significantly better discriminative power than the ISS in MM patients treated with novel agents as a primary therapy. However, it does not better reclassify patients from the ISS, suggesting that there is still room to improve the staging system. Moreover, new statistical measures for assessing and quantifying the risk prediction of new prognostic models are necessary in future studies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF HEMATOLOGY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | WORKING GROUP | - |
dc.subject | SURVIVAL | - |
dc.subject | MODEL | - |
dc.subject | STRATIFICATION | - |
dc.subject | PREDICTION | - |
dc.subject | LYMPHOMA | - |
dc.title | Comprehensive evaluation of the revised international staging system in multiple myeloma patients treated with novel agents as a primary therapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000414628800012 | - |
dc.identifier.doi | 10.1002/ajh.24891 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF HEMATOLOGY, v.92, no.12, pp.1280 - 1286 | - |
dc.identifier.scopusid | 2-s2.0-85029229686 | - |
dc.citation.endPage | 1286 | - |
dc.citation.startPage | 1280 | - |
dc.citation.title | AMERICAN JOURNAL OF HEMATOLOGY | - |
dc.citation.volume | 92 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | WORKING GROUP | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | STRATIFICATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | LYMPHOMA | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.