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Immune-stimulating activity of water-soluble extracellular polysaccharide isolated from Rhizobium massiliae

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dc.contributor.authorKim, Joo Won-
dc.contributor.authorLee, Jisun-
dc.contributor.authorYoo, Ah Young-
dc.contributor.authorChoi, Ji Won-
dc.contributor.authorPark, Yong Il-
dc.contributor.authorPark, Jae Kweon-
dc.date.available2020-02-27T16:42:04Z-
dc.date.created2020-02-06-
dc.date.issued2017-12-
dc.identifier.issn1359-5113-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5428-
dc.description.abstractThe aim of this study is to investigate biochemical properties of water-soluble extracellular polysaccharide (WSP) from a novel bacterial strain designated to CA-1 and classified to Rhizobiun massiliae by 16S rDNA sequence determination and homology analysis. The main composition of WSP was determined to be glucose by HPAEC. We evaluated immunomodulatory effects of WSP on RAW 264.7 macrophage activation. The results showed that the WSP dose-dependently induced the release of the pro-inflammatory cytokines such as TNF-alpha and IL-6. In addition, WSP induced nitric oxide synthase (iNOS) expression and increased the production of nitric oxide (NO). Intriguingly, WSP remarkably increased the mRNA expression of Toll-like receptor-2 (TLR-2) and the phosphorylation of MAPKs (ERK, JNK and p38) in RAW 264.7 cells. These results indicated that WSP activates macrophages to secrete pro-inflammatory cytokines and induces iNOS expression via the activation of the TLR-2/MAPKs signaling pathways. Conclusively, we suggest that WSP of R. massiliae CA-1 can be a new immunomodulatory enhancing the early innate immunity.-
dc.language영어-
dc.language.isoen-
dc.publisherELSEVIER SCI LTD-
dc.relation.isPartOfPROCESS BIOCHEMISTRY-
dc.subjectBROWN-ALGAE-
dc.subjectPURIFICATION-
dc.subjectALPHA-
dc.subjectEXOPOLYSACCHARIDES-
dc.subjectADJUVANT-
dc.subjectFUCOIDAN-
dc.subjectBACTERIA-
dc.subjectAGONISTS-
dc.subjectSTRAIN-
dc.subjectCELLS-
dc.titleImmune-stimulating activity of water-soluble extracellular polysaccharide isolated from Rhizobium massiliae-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000418222500030-
dc.identifier.doi10.1016/j.procbio.2017.09.005-
dc.identifier.bibliographicCitationPROCESS BIOCHEMISTRY, v.63, pp.236 - 243-
dc.identifier.scopusid2-s2.0-85029545813-
dc.citation.endPage243-
dc.citation.startPage236-
dc.citation.titlePROCESS BIOCHEMISTRY-
dc.citation.volume63-
dc.contributor.affiliatedAuthorKim, Joo Won-
dc.contributor.affiliatedAuthorPark, Jae Kweon-
dc.type.docTypeArticle-
dc.subject.keywordAuthorRhizobium massiliae-
dc.subject.keywordAuthorWater-soluble polysaccharide-
dc.subject.keywordAuthorImmune-stimulation-
dc.subject.keywordAuthorPro-inflammatory cytokines-
dc.subject.keywordPlusBROWN-ALGAE-
dc.subject.keywordPlusPURIFICATION-
dc.subject.keywordPlusALPHA-
dc.subject.keywordPlusEXOPOLYSACCHARIDES-
dc.subject.keywordPlusADJUVANT-
dc.subject.keywordPlusFUCOIDAN-
dc.subject.keywordPlusBACTERIA-
dc.subject.keywordPlusAGONISTS-
dc.subject.keywordPlusSTRAIN-
dc.subject.keywordPlusCELLS-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryEngineering, Chemical-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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