Administration of a Sol-Gel Formulation of Phenylephrine Using Low-Temperature Hollow Microneedle for Treatment of Intermittent Fecal Incontinence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.contributor.author | Park, Jung Ho | - |
dc.date.available | 2020-02-27T16:42:05Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0724-8741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5429 | - |
dc.description.abstract | A low temperature hollow microneedle system was devised to deliver sol-gel transition formulation near the surface of the skin for extended release and local delivery of drug by a non-invasive method. This new system can improve treatment of intermittent fecal incontinence. The low-temperature system was integrated with a hollow microneedle to maintain the low temperature of the sol formulation. Various sol-gel formulations using Pluronic F-127 (PF-127) and Hydroxy-propyl-methyl-cellulose (HPMC) were prepared, and their gelation temperature, flow property, and diffusion retardation were observed. Resting anal sphincter pressure in response to a phenylephrine (PE) sol-gel formulation was measured using an air-charged catheter. The biocompatibility of the sol-gel PE formulation was evaluated by observing the immunological response. When the PF-127 25%, HPMC 1% and PE formulation (PF25-HPMC1-PE) was injected through the peri-anal skin of the rat in vivo, the highest pressure on the anal sphincter muscle occurred at 6-8 h and anal pressure increased and lasted twice as long as with the phosphate-buffered saline (PBS)-PE formulation. There was no significant difference in the number of mast cells after administration into the rat in vivo between the PF25-HPMC1-PE formulation and the PBS-PE formulation. The combination of a low-pain hollow microneedle system and an injectable sol-gel formulation improved the efficacy of treatment of intermittent fecal incontinence. A low-temperature hollow microneedle system using a sol-gel formulation has many applications in medical treatments that require depot effect, local targeting, and pain control. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.relation.isPartOf | PHARMACEUTICAL RESEARCH | - |
dc.subject | TOPICAL PHENYLEPHRINE | - |
dc.subject | DELIVERY | - |
dc.subject | DRUG | - |
dc.subject | VACCINE | - |
dc.subject | RELEASE | - |
dc.subject | PAIN | - |
dc.title | Administration of a Sol-Gel Formulation of Phenylephrine Using Low-Temperature Hollow Microneedle for Treatment of Intermittent Fecal Incontinence | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000418390000030 | - |
dc.identifier.doi | 10.1007/s11095-017-2261-9 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL RESEARCH, v.34, no.12, pp.2809 - 2816 | - |
dc.identifier.scopusid | 2-s2.0-85035126509 | - |
dc.citation.endPage | 2816 | - |
dc.citation.startPage | 2809 | - |
dc.citation.title | PHARMACEUTICAL RESEARCH | - |
dc.citation.volume | 34 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Hyunji | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | intermittent occurrence offecal incontinence | - |
dc.subject.keywordAuthor | local targeting | - |
dc.subject.keywordAuthor | low pain | - |
dc.subject.keywordAuthor | low temperature hollow microneedle | - |
dc.subject.keywordAuthor | sol-gel formulation | - |
dc.subject.keywordPlus | TOPICAL PHENYLEPHRINE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PAIN | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.