Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
DC Field | Value | Language |
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dc.contributor.author | Hwang, Ji An | - |
dc.contributor.author | Song, Joo Han | - |
dc.contributor.author | Kim, Jung Hoon | - |
dc.contributor.author | Chung, Man Pyo | - |
dc.contributor.author | Kim, Dong Soon | - |
dc.contributor.author | Song, Jin Woo | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Cha, Seung Ick | - |
dc.contributor.author | Uh, Soo Taek | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.contributor.author | Park, Yong Bum | - |
dc.contributor.author | Lee, Hong Lyeol | - |
dc.contributor.author | Shin, Jong Wook | - |
dc.contributor.author | Lee, Eun Joo | - |
dc.contributor.author | Jegal, Yangjin | - |
dc.contributor.author | Lee, Hyun Kyung | - |
dc.contributor.author | Park, Jong Sun | - |
dc.contributor.author | Park, Moo Suk | - |
dc.date.available | 2020-02-27T16:42:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-11-21 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5474 | - |
dc.description.abstract | Background: This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP. Methods: We retrospectively reviewed medical records of 78 Korean PAP patients diagnosed between 1993 and 2014. Patients were classified into two groups according to the presence/absence of treatment (lavage). Clinical and laboratory features were compared between the two groups. Results: Of the total 78 PAP patients, 60% were male and median age at diagnosis was 47.5 years. Fifty three percent were ever smokers (median 22 pack-years) and 48% had a history of dust exposure (metal 26.5%, stone or sand 20.6%, chemical or paint 17.7%, farming dust 14.7%, diesel 14.7%, textile 2.9%, and wood 2.9%). A history of cigarette smoking or dust exposure was present in 70.5% of the total PAP patients, with 23% having both of them. Patients who underwent lavage (n = 38) presented symptoms more frequently (38/38 [100%] vs. 24/40 [60%], P < 0.001) and had significantly lower PaO2 and DLCO with higher D(A-a) O-2 at the onset of disease than those without lavage (n = 40) (P = 0.006, P < 0.001, and P = 0.036, respectively). Correspondingly, the distribution of disease severity score (DSS) differed significantly between the two groups (P = 0.001). Based on these, when the total patients were categorized according to DSS (low DSS [DSS 1-2] vs. high DSS [DSS 3-5]), smoking status differed significantly between the two groups with the proportion of current smokers significantly higher in the high DSS group (11/22 [50%] vs. 7/39 [17.9%], P = 0.008). Furthermore, current smokers had meaningfully higher DSS and serum CEA levels than non-current smokers (P = 0.011 and P = 0.031), whereas no difference was found between smokers and non-smokers. Regarding type of exposed dust, farming dust was significantly associated with more severe form of PAP (P = 0.004). Conclusion: A considerable proportion of PAP patients had a history of cigarette smoking and/or dust exposure, suggestive of their possible roles in the development of PAP. Active cigarette smoking at the onset of PAP is associated with the severity of PAP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.isPartOf | BMC PULMONARY MEDICINE | - |
dc.subject | INCREASED CARCINOEMBRYONIC ANTIGEN | - |
dc.subject | BRONCHOALVEOLAR LAVAGE | - |
dc.subject | BASEMENT-MEMBRANE | - |
dc.subject | COTTON DUST | - |
dc.subject | GM-CSF | - |
dc.subject | EPITHELIAL PERMEABILITY | - |
dc.subject | TUMOR-MARKERS | - |
dc.subject | IN-VITRO | - |
dc.subject | TOXICITY | - |
dc.subject | ANTIBODY | - |
dc.title | Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000416046100003 | - |
dc.identifier.doi | 10.1186/s12890-017-0493-4 | - |
dc.identifier.bibliographicCitation | BMC PULMONARY MEDICINE, v.17 | - |
dc.identifier.scopusid | 2-s2.0-85034656135 | - |
dc.citation.title | BMC PULMONARY MEDICINE | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Jeong, Sung Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Disease severity | - |
dc.subject.keywordAuthor | Dust exposure | - |
dc.subject.keywordAuthor | Pulmonary alveolar proteinosis | - |
dc.subject.keywordAuthor | Smoking | - |
dc.subject.keywordPlus | INCREASED CARCINOEMBRYONIC ANTIGEN | - |
dc.subject.keywordPlus | BRONCHOALVEOLAR LAVAGE | - |
dc.subject.keywordPlus | BASEMENT-MEMBRANE | - |
dc.subject.keywordPlus | COTTON DUST | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | EPITHELIAL PERMEABILITY | - |
dc.subject.keywordPlus | TUMOR-MARKERS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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