The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Mee-Sup | - |
dc.date.available | 2020-02-27T16:42:57Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5494 | - |
dc.description.abstract | The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.subject | DIET-INDUCED OBESITY | - |
dc.subject | AMINO-ACID LEVELS | - |
dc.subject | BETA-CELL MASS | - |
dc.subject | RECEPTOR SUBSTRATE-1 | - |
dc.subject | PHOSPHATIDIC-ACID | - |
dc.subject | RAG GTPASES | - |
dc.subject | SERINE/THREONINE PHOSPHORYLATION | - |
dc.subject | STIMULATED PHOSPHORYLATION | - |
dc.subject | HEPATIC GLUCONEOGENESIS | - |
dc.subject | GLUCOSE-HOMEOSTASIS | - |
dc.title | The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000416547200014 | - |
dc.identifier.doi | 10.3390/nu9111176 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.9, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85032575486 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Yoon, Mee-Sup | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | insulin | - |
dc.subject.keywordAuthor | mammalian target of rapamycin (mTOR) | - |
dc.subject.keywordAuthor | mTOR complex1 (mTORC1) | - |
dc.subject.keywordAuthor | mTOR complex2 (mTORC2) | - |
dc.subject.keywordAuthor | protein kinase B (PKB | - |
dc.subject.keywordAuthor | Akt) | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | AMINO-ACID LEVELS | - |
dc.subject.keywordPlus | BETA-CELL MASS | - |
dc.subject.keywordPlus | RECEPTOR SUBSTRATE-1 | - |
dc.subject.keywordPlus | PHOSPHATIDIC-ACID | - |
dc.subject.keywordPlus | RAG GTPASES | - |
dc.subject.keywordPlus | SERINE/THREONINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | STIMULATED PHOSPHORYLATION | - |
dc.subject.keywordPlus | HEPATIC GLUCONEOGENESIS | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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