Synthesis and Characterization of Chitosan-Coated Hydrogel Composites for an Efficient Drug Delivery System
- Authors
- Bae, Saet Byeol; Jung, Won Sik; Kook, Jeong Keun; Lee, Sang-Wha
- Issue Date
- Nov-2017
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Hydrogel; Chitosan; Alginate; Ibuprofen; Drug Delivery
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.17, no.11, pp.8001 - 8006
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 17
- Number
- 11
- Start Page
- 8001
- End Page
- 8006
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5533
- DOI
- 10.1166/jnn.2017.15078
- ISSN
- 1533-4880
- Abstract
- Silica nanoparticles (SNPs) with hydrogel capsule layer was easily prepared via radical polymerization of co-monomers N-isopropylacrylamide and acrylic acid in 96: 4 and 91: 9 wt% on the olefin terminated surface of SNPs. The hydrogel-encapsulated SNPs (SNPs@Hyd) have carboxylic acid groups, which can bind alternatively chitosan/alginate/chitosan chains to enhance the structural integrity of hydrogel composites. Chitosan-coated SNPs@Hyd exhibited prolonged releasing times of absorbed ibuprofens from hydrogel capsules entangled by alternative chitosan/alginate/chitosan chains. In particular, double chitosan-coated SNPs@Hyd (SNPs@Hyd@Chi@Algi@Chi) absorbed larger amount of ibuprofen than that of single chitosan-coated SNPs@ Hyd (SNPs@Hyd@Chi), demonstrating a chemical strategy for preparing an efficient drug delivery system.
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