Protection Effect of Cyanidin 3-O-Glucoside Against Oxidative Stress-induced HepG2 Cell Death Through Activation of Akt and Extracellular Signal-regulated Kinase Pathways
DC Field | Value | Language |
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dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.available | 2020-02-27T16:43:35Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5538 | - |
dc.description.abstract | The attack of reactive oxygen species (ROS) on unsaturated fatty acids causes peroxidation. The membranes of liver cells are rich in unsaturated fatty acids, which are a target of lipid peroxidation by free radicals. The purpose of the present study was to identify the hepatoprotective potential of Lonicera caerulea and its active compound, cyanidin 3-O-glucoside, on tertiary butyl hydroperoxide (tBHP)-induced oxidative damage in HepG2 cells. L. caerulea extract and its active compound, cyanidin 3-O-glucoside, showed a dose-dependent hepatoprotective effect on tBHP-induced HepG2 cell damage. In addition, L. caerulea and cyanidin 3-O-glucoside inhibited the production of intracellular ROS in tBHP-treated HepG2 cells. The protein expression of phosphorylated-extracellular signal-regulated kinases and Akt, which are responsible for cell protection against ROS, were increased after treatment with cyanidin 3-O-glucoside (50 and 100 mu M) in a dose-dependent manner. Therefore, cyanidin 3-O-glucoside is the active compound in L. caerulea, which is responsible for the hepatoprotective effects through the inhibition of ROS and the activation of antioxidant mechanisms. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.title | Protection Effect of Cyanidin 3-O-Glucoside Against Oxidative Stress-induced HepG2 Cell Death Through Activation of Akt and Extracellular Signal-regulated Kinase Pathways | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000414972400011 | - |
dc.identifier.doi | 10.1002/bkcs.11290 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.38, no.11, pp.1316 - 1320 | - |
dc.identifier.kciid | ART002283222 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85031687863 | - |
dc.citation.endPage | 1320 | - |
dc.citation.startPage | 1316 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 38 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Park, Jun Yeon | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cyanidin 3-O-glucoside | - |
dc.subject.keywordAuthor | Tertiary butyl hydroperoxide | - |
dc.subject.keywordAuthor | Extracellular signal-regulated kinases | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | FRUIT | - |
dc.subject.keywordPlus | L. | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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