Exploration of changes in the brain response to sleep-related pictures after cognitive-behavioral therapy for psychophysiological insomnia
DC Field | Value | Language |
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dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Kim, Nambeom | - |
dc.contributor.author | Kim, Soohyun | - |
dc.contributor.author | Choi, Jae-Won | - |
dc.contributor.author | Park, Juhyun | - |
dc.contributor.author | Gwak, Ah Reum | - |
dc.contributor.author | Kang, Chang-Ki | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Jeong, Do-Un | - |
dc.date.available | 2020-02-27T16:44:09Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-10-02 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5590 | - |
dc.description.abstract | Psychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), which can be treated by cognitive behavioral therapy for insomnia (CBT-I). The present study was an exploratory, prospective intervention study that aimed to explore brain response to visual SS in PI before and after CBT-I. Blood oxygen level dependent (BOLD) signal differences in response to SS and neutral stimuli (NS) were compared between 14 drug-free PI patients and 18 good sleepers (GS) using functional magnetic resonance imaging (fMRI). BOLD changes after CBT-I in patients were also examined. PI patients showed higher BOLD activation to SS in the precentral, prefrontal, fusiform, and posterior cingulate cortices before CBT-I. The increased responses to SS were reduced after CBT-I. The increased response to SS in the precentral cortex was associated with longer wake time after sleep onset (WASO), and its reduction after CBT-I was associated with improvements in WASO. Clinical improvements after CBT-I were correlated with BOLD reduction in the right insula and left paracentral cortex in response to SS. PI showed hyper-responses to SS in the precentral cortex, prefrontal cortex, and default mode network and these brain hyper-responses were normalized after CBT-I. CBT-I may exert its treatment effects on PI by reducing hyper-responses to SS in the precentral cortex and insula. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | DEFAULT MODE NETWORK | - |
dc.subject | ATTENTIONAL BIAS | - |
dc.subject | DISORDER | - |
dc.subject | CONNECTIVITY | - |
dc.subject | VALIDATION | - |
dc.subject | VERSION | - |
dc.subject | CORTEX | - |
dc.subject | ADULTS | - |
dc.subject | INDEX | - |
dc.title | Exploration of changes in the brain response to sleep-related pictures after cognitive-behavioral therapy for psychophysiological insomnia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000412050100049 | - |
dc.identifier.doi | 10.1038/s41598-017-13065-0 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.identifier.scopusid | 2-s2.0-85030543464 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Nambeom | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Ki | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DEFAULT MODE NETWORK | - |
dc.subject.keywordPlus | ATTENTIONAL BIAS | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | VERSION | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | INDEX | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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