Antihypertensive effect of an enzymatic hydrolysate from Styela clava flesh tissue in type 2 diabetic patients with hypertension
- Authors
- Ko, Seok-Chun; Jung, Won-Kyo; Lee, Seung-Hong; Lee, Dae Ho; Jeon, You-Jin
- Issue Date
- Oct-2017
- Publisher
- KOREAN NUTRITION SOC
- Keywords
- Aquatic organisms; protein hydrolysates; clinical trial; antihypertensive agents
- Citation
- NUTRITION RESEARCH AND PRACTICE, v.11, no.5, pp.396 - 401
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- Volume
- 11
- Number
- 5
- Start Page
- 396
- End Page
- 401
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5618
- DOI
- 10.4162/nrp.2017.11.5.396
- ISSN
- 1976-1457
- Abstract
- BACGROUND/OBJECTIVES: In this randomized, placebo-controlled, double-blind study, we evaluated the antihypertensive effects of enzymatic hydrolysate from Styela clava flesh tissue in patients with type 2 diabetes mellitus (T2DM) and hypertension. SUBJECTS/METHODS: S. clava flesh tissue hydrolysate (SFTH) (n = 34) and placebo (n = 22) were randomly allocated to the study subjects. Each subject ingested two test capsules (500 mg) containing powdered SFTH (SFTH group) or placebo capsules (placebo group) during four weeks. RESULTS: In the SFTH group, systolic and diastolic blood pressure decreased significantly 4 weeks after ingestion by 9.9 mmHg (P < 0.01) and 7.8 mmHg (P < 0.01), respectively. In addition, the SFTH group exhibited a significant decrease in hemoglobin A(lc) with a tendency toward improvement in homeostasis model assessment of insulin resistance, triglyceride, apolipoprotein B and plasma insulin levels after 4 weeks. No adverse effects were observed in other indexes, including biochemical and hematological parameters in both groups. CONCLUSION: The results of our study suggested that SFTH exerts a regulatory, antihypertensive effect in patients with T2DM and hypertension.
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