8-Hydroxy-2-deoxyguanosine ameliorates high-fat diet-induced insulin resistance and adipocyte dysfunction in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huh, Joo Young | - |
dc.contributor.author | Jung, Inji | - |
dc.contributor.author | Piao, Lingjuan | - |
dc.contributor.author | Ha, Hunjoo | - |
dc.contributor.author | Chung, Myung-Hee | - |
dc.date.available | 2020-02-27T17:41:51Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09-30 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5688 | - |
dc.description.abstract | 8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been recently shown to exert anti-inflammatory effects through inhibition of Racl. Inflammation in adipose tissue is a hallmark of obesity-induced insulin resistance, but the therapeutic potential of 8-OHdG in treatment of metabolic diseases has not been fully elucidated. The aim of this study was to examine the effect of exogenously administered 8-OHdG on adipose tissue and whole body metabolism. In cultured adipocytes, 8-OHdG inhibited adipogenesis and reversed TNF alpha-induced insulin resistance. In high-fat diet (HFD)-induced obese mice, 8-OHdG administration blunted the rise in body weight and fat mass. The decrease in adipose tissue mass by 8-OHdG was due to reduced adipocyte hypertrophy through induction of adipose triglyceride lipase and inhibition of fatty acid synthase expression. 8-OHdG also inhibited the infiltration of macrophages, resulting in amelioration of adipose tissue inflammation and adipokine dysregulation. Moreover, 8-OHdG administration ameliorated adipocyte as well as systemic insulin sensitivity. Both in vivo and in vitro results showed that 8-OHdG induces AMPK activation and reduces JNK activation in adipocytes. In conclusion, our results show that orally administered 8-OHdG protects against HFD-induced metabolic disorders by regulating adipocyte metabolism. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | OBESITY | - |
dc.subject | ADIPONECTIN | - |
dc.subject | MECHANISMS | - |
dc.subject | INJURY | - |
dc.subject | DAMAGE | - |
dc.subject | RAC | - |
dc.subject | DNA | - |
dc.title | 8-Hydroxy-2-deoxyguanosine ameliorates high-fat diet-induced insulin resistance and adipocyte dysfunction in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000411169800005 | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.07.132 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.491, no.4, pp.890 - 896 | - |
dc.identifier.scopusid | 2-s2.0-85026357962 | - |
dc.citation.endPage | 896 | - |
dc.citation.startPage | 890 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 491 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Chung, Myung-Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 8-Hydroxy-2-deoxyguanosine | - |
dc.subject.keywordAuthor | Adipocyte metabolism | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | RAC | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.