In vitro and in vivo behavior of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin delivery
DC Field | Value | Language |
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dc.contributor.author | Kang, Ji Hee | - |
dc.contributor.author | Kim, Kyoung-Ran | - |
dc.contributor.author | Lee, Hyukjin | - |
dc.contributor.author | Ahn, Dae-Ro | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-27T17:42:13Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5713 | - |
dc.description.abstract | Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td). L-Td molecules of two different sizes one with 17-mer per side (L-Td(17)) and the other with 30-mer per side (L-Td(30)) were prepared by assembling four L-DNA strands. In this study, cellular uptake of L-Td with different sizes was observed over time using a laser scanning confocal microscope (LSCM) equipped with a live cell chamber system. In addition, we conducted a pharmacokinetic study to examine the potential of L-Td as a carrier for in vivo tumor-targeted delivery of a low dose of doxorubicin (DOX). L-Td entered into the cells through endocytosis, and a specific DNA sequence of the L-Td ensures targeted entry into cancer cells. Compared with free DOX, DOX-loaded L-Td (DOX@L-Td) showed decreased clearance and increased initial concentration (C-0), half-life, and area under the curve (AUC), indicating that DOX@L-Td circulated in the blood stream for longer than free DOX. L-Td(17), in particular, had beneficial effects owing to its ability to enhance tumor accumulation of DOX and reduce the cardiotoxicity caused by it through administration of a low dose of the drug. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.subject | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CANCER-CHEMOTHERAPY | - |
dc.subject | THERAPY | - |
dc.subject | NANOSTRUCTURES | - |
dc.subject | NANOTECHNOLOGY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | LIPOSOMES | - |
dc.subject | TOXICITY | - |
dc.subject | SYSTEMS | - |
dc.title | In vitro and in vivo behavior of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin delivery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000408597900049 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2017.06.014 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.157, pp.424 - 431 | - |
dc.identifier.scopusid | 2-s2.0-85020917070 | - |
dc.citation.endPage | 431 | - |
dc.citation.startPage | 424 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 157 | - |
dc.contributor.affiliatedAuthor | Kang, Ji Hee | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | DNA nanostructure | - |
dc.subject.keywordAuthor | DNA tetrahedron | - |
dc.subject.keywordAuthor | Tumor-targeted delivery | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | Live cell imaging | - |
dc.subject.keywordPlus | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CANCER-CHEMOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | NANOTECHNOLOGY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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