Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Shibamoto, Takayuki | - |
dc.contributor.author | Jang, Tae Su | - |
dc.contributor.author | Lee, Sang Cheon | - |
dc.contributor.author | Shim, Jae Suk | - |
dc.contributor.author | Hahm, Dae-Hyun | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T17:42:15Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5716 | - |
dc.description.abstract | The biological activities of the ethanol extract from Cirsium japonicum var. maackii (ICF-1) and its major component, polyphenol cirsimaritin, were investigated as part of the search for possible alternative drugs for breast cancer. Three in vitro cell-based assays were used: the cell proliferation assay, tube-formation assay, and Western blot analysis. Both the ICF-1 extract and cirsimaritin inhibited the viability of HUVECs in a dose-dependent manner. The inhibition achieved was 36.89% at a level of 200 mu g/ml by the ICF-1 extract and 62.04% at a level of 100 mu M by cirsimaritin. The ICF-1 extract and cirsimaritin reduced tube formation by 12.69% at level of 25 mu g/ml and 32.18% at the levels of 6.25 mu M, respectively. Cirsimaritin inhibited angiogenesis by downregulation of VEGF, p-Akt and p-ERK in MDA-MB-231 cells, suggesting that cirsimaritin is potentially useful as an anti-metastatic agent. The present study demonstrated that Cirsium japonicum extract and its active component cirsimaritin is an excellent candidate as an alternative anti-breast cancer drug. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | USSURIENSE | - |
dc.subject | PREVENTION | - |
dc.subject | PRINCIPLE | - |
dc.subject | FLAVONE | - |
dc.subject | LINES | - |
dc.subject | MICE | - |
dc.title | Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000410462500006 | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.07.070 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.17, pp.3968 - 3973 | - |
dc.identifier.scopusid | 2-s2.0-85026768301 | - |
dc.citation.endPage | 3973 | - |
dc.citation.startPage | 3968 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 27 | - |
dc.citation.number | 17 | - |
dc.contributor.affiliatedAuthor | Park, Jun Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cirsium japonicum var. maackii | - |
dc.subject.keywordAuthor | Cirsimaritin | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Natural plant extract | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | USSURIENSE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PRINCIPLE | - |
dc.subject.keywordPlus | FLAVONE | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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