Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ohashi, Natsuko | - |
dc.contributor.author | Morino, Katsutaro | - |
dc.contributor.author | Ida, Shogo | - |
dc.contributor.author | Sekine, Osamu | - |
dc.contributor.author | Lemecha, Mengistu | - |
dc.contributor.author | Kume, Shinji | - |
dc.contributor.author | Park, Shi-Young | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Ugi, Satoshi | - |
dc.contributor.author | Maegawa, Hiroshi | - |
dc.date.available | 2020-02-27T17:42:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5720 | - |
dc.description.abstract | Adipose tissues considerably influence metabolic homeostasis, and both white (WAT) and brown (BAT) adipose tissue play significant roles in lipid and glucose metabolism. O-linked N-acetylglucosamine (O-GlcNAc) modification is characterized by the addition of N-acetylglucosamine to various proteins by O-GlcNAc transferase (Ogt), subsequently modulating various cellular processes. However, little is known about the role of O-GlcNAc modification in adipose tissues. Here, we report the critical role of O-GlcNAc modification in cold-induced thermogenesis. Deletion of Ogt in WAT and BAT using adiponectin promoterdriven Cre recombinase resulted in severe cold intolerance with decreased uncoupling protein 1 (Ucp1) expression. Furthermore, Ogt deletion led to decreased mitochondrial protein expression in conjunction with decreased peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein expression. This phenotype was further confirmed by deletion of Ogt in BAT using Ucp1 promoter-driven Cre recombinase, suggesting that O-GlcNAc modification in BAT is responsible for cold-induced thermogenesis. Hypothermia was significant under fasting conditions. This effect was mitigated after normal diet consumption but not after consumption of a fatty acid-rich ketogenic diet lacking carbohydrates, suggesting impaired diet-induced thermogenesis, particularly by fat. In conclusion, O-GlcNAc modification is essential for cold-induced thermogenesis and mitochondrial biogenesis in BAT. Glucose flux into BAT may be a signal to maintain BAT physiological responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.relation.isPartOf | DIABETES | - |
dc.subject | TRANSCRIPTIONAL COACTIVATOR | - |
dc.subject | ENERGY-EXPENDITURE | - |
dc.subject | CHRONIC DISEASE | - |
dc.subject | ADULT HUMANS | - |
dc.subject | METABOLISM | - |
dc.subject | PGC-1-ALPHA | - |
dc.subject | PGC-1 | - |
dc.subject | COMPLEX | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INFLAMMATION | - |
dc.title | Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000408156600005 | - |
dc.identifier.doi | 10.2337/db16-1427 | - |
dc.identifier.bibliographicCitation | DIABETES, v.66, no.9, pp.2351 - 2362 | - |
dc.identifier.scopusid | 2-s2.0-85028041739 | - |
dc.citation.endPage | 2362 | - |
dc.citation.startPage | 2351 | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 66 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Park, Shi-Young | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL COACTIVATOR | - |
dc.subject.keywordPlus | ENERGY-EXPENDITURE | - |
dc.subject.keywordPlus | CHRONIC DISEASE | - |
dc.subject.keywordPlus | ADULT HUMANS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
dc.subject.keywordPlus | PGC-1 | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.