Aggressive Imaging Features in a Malignant Pheochromocytoma With a Novel Mutation of the SDHB Gene
- Authors
- Park, Soon-Ah; Lee, Dae Ho; Kim, Hun Soo
- Issue Date
- Sep-2017
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- MIBG; mutation; PET; CT; pheochromocytomas; succinate dehydrogenase subunit B
- Citation
- CLINICAL NUCLEAR MEDICINE, v.42, no.9, pp.687 - 689
- Journal Title
- CLINICAL NUCLEAR MEDICINE
- Volume
- 42
- Number
- 9
- Start Page
- 687
- End Page
- 689
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5732
- DOI
- 10.1097/RLU.0000000000001729
- ISSN
- 0363-9762
- Abstract
- We describe a 15-year-old boy with a huge bilateral adrenal pheochromocytoma that had a de novo germline mutation in the succinate dehydrogenase subunit B (SDHB) gene. F-18-FDG PET/CT revealed bilateral metabolically active large masses in the adrenal glands and the activated brown adipose tissues. The I-123-MIBG scintigraphic findings revealed only a mild accumulation of MIBG in the right adrenal mass, but a high uptake in the left adrenal mass. Thus, F-18-FDG PET/CT imaging may be more effective than I-123-MIBG scintigraphy for the evaluation of pheochromocytomas that are associated with highly malignant characteristics resulting from mutations of the SDHB gene.
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