The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Eun | - |
dc.contributor.author | Shin, Dongseong | - |
dc.contributor.author | Gu, Namyi | - |
dc.contributor.author | Jung, Byung Hwa | - |
dc.contributor.author | Kim, Jayoun | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.date.available | 2020-02-27T17:42:49Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5763 | - |
dc.description.abstract | Rosuvastatin is an HMG-CoA reductase inhibitor widely used for treating hypercholesterolaemia. We investigated whether genetic polymorphisms in solute carrier organic anion transporter 2B1 (SLCO2B1) affect the lipid-lowering effect of rosuvastatin in healthy adults with elevated low-density lipoprotein (LDL). This study included 18 volunteers with LDL levels above 130 mg/dL. Rosuvastatin (20 mg) was administered once a day for 8 weeks. Blood samples were drawn before and after the 8-week treatment to measure changes in lipid levels. The presence of single nucleotide polymorphisms (SNPs) of SLCO2B1 (c.935G>A and c.1457C>T), SLCO1B1 (c.521C>T, c.388A>G and c.-11187G>A) and ABCG2 (c.421C>A) was determined by genotyping. Responses to rosuvastatin were compared between wild-type and variant genotypes using permutation test on each polymorphism. In volunteers with SLCO2B1 c.935G>A (rs12422149) variant, rosuvastatin was less effective at lowering LDL (mean % decrease: GG 62.8% GA 50.6% AA 49.3%, p = 0.012) and apoprotein B (mean % decrease: GG 52.1% GA 42.8% AA 42.8%, p = 0.036). Regarding SLCO2B1 c.1457C>T (rs2306168) SNP, there was no significant difference between wild-type and variant genotypes. This study demonstrated that SLCO2B1 c.935G>A (rs12422149) polymorphism influenced the lipid-lowering effects of rosuvastatin in volunteers with hypercholesterolaemia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | - |
dc.subject | PLASMA-CONCENTRATIONS | - |
dc.subject | ABCG2 POLYMORPHISM | - |
dc.subject | APPLE JUICE | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | MONTELUKAST | - |
dc.subject | SLCO1B1 | - |
dc.subject | CHINESE | - |
dc.subject | FEXOFENADINE | - |
dc.subject | TRANSPORTERS | - |
dc.subject | ABSORPTION | - |
dc.title | The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000407572900007 | - |
dc.identifier.doi | 10.1111/bcpt.12826 | - |
dc.identifier.bibliographicCitation | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v.121, no.3, pp.195 - 201 | - |
dc.identifier.scopusid | 2-s2.0-85022337998 | - |
dc.citation.endPage | 201 | - |
dc.citation.startPage | 195 | - |
dc.citation.title | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | - |
dc.citation.volume | 121 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Shin, Dongseong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PLASMA-CONCENTRATIONS | - |
dc.subject.keywordPlus | ABCG2 POLYMORPHISM | - |
dc.subject.keywordPlus | APPLE JUICE | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | MONTELUKAST | - |
dc.subject.keywordPlus | SLCO1B1 | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | FEXOFENADINE | - |
dc.subject.keywordPlus | TRANSPORTERS | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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