In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Jun-Won | - |
dc.contributor.author | Kim, Su Young | - |
dc.contributor.author | Park, Hee Jung | - |
dc.contributor.author | Chung, Chang Su | - |
dc.contributor.author | Lee, Hee Woo | - |
dc.contributor.author | Lee, Sun Mi | - |
dc.contributor.author | Kim, Inki | - |
dc.contributor.author | Pak, Jhang Ho | - |
dc.contributor.author | Lee, Gin Hyug | - |
dc.contributor.author | Jeong, Jin-Yong | - |
dc.date.available | 2020-02-27T17:42:58Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5779 | - |
dc.description.abstract | Background/Aims: The increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity. Methods: We screened a small molecule library the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds to identify inhibitors of H. pylori growth. The minimal inhibitory concentrations (MICs) of antibiotics against multidrug-resistant H. pylori strains were determined using the agar dilution method. Results: We identified diphenyleneiodonium (DPI) as a novel anti H. pylori agent. The MIC values for DPI were <0.03 mu g/mL against all tested H. pylori strains. DPI also exhibited strong antibacterial activity against common gram-negative and gram-positive pathogenic bacteria. Conclusions: DPI may be a candidate anti-H. pylori drug for future development. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.subject | GASTRIC EPITHELIAL-CELLS | - |
dc.subject | NADPH OXIDASE | - |
dc.subject | TRIPLE THERAPY | - |
dc.subject | ERADICATION | - |
dc.subject | EXPRESSION | - |
dc.subject | INFECTION | - |
dc.subject | METRONIDAZOLE | - |
dc.subject | AMOXICILLIN | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITORS | - |
dc.title | In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000411046200011 | - |
dc.identifier.doi | 10.5009/gnl16503 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.11, no.5, pp.648 - 654 | - |
dc.identifier.kciid | ART002262822 | - |
dc.identifier.scopusid | 2-s2.0-85032028848 | - |
dc.citation.endPage | 654 | - |
dc.citation.startPage | 648 | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Chung, Jun-Won | - |
dc.contributor.affiliatedAuthor | Kim, Su Young | - |
dc.contributor.affiliatedAuthor | Chung, Chang Su | - |
dc.contributor.affiliatedAuthor | Lee, Hee Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Diphenyleneiodonium | - |
dc.subject.keywordAuthor | Drug resistance, multiple | - |
dc.subject.keywordAuthor | Anti-bacterial agents | - |
dc.subject.keywordAuthor | Minimal inhibitory concentration | - |
dc.subject.keywordPlus | GASTRIC EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | TRIPLE THERAPY | - |
dc.subject.keywordPlus | ERADICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | METRONIDAZOLE | - |
dc.subject.keywordPlus | AMOXICILLIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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