Ester alkaloids from Cephalotaxus interfere with the 2'3'-cGAMP-induced type I interferon pathway in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Gayoung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.date.available | 2020-02-27T17:43:39Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-08-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5824 | - |
dc.description.abstract | Dysregulated activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway by self-DNA contributes to interferonopathy and promotes autoimmune diseases. To identify potential suppressors of STING-induced type I interferon (IFN) induction, ethanol extracts of medicinal plants were screened for inhibitory activity against IFN-beta promoter activation. Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING-induced, but not TBK1-or IRF3-induced, IFN-beta promoter activity. The compounds exerting inhibitory activity specifically against STING-mediated IFN-beta promoter activation were identified as ester alkaloids isolated from the genus, Cephalotaxus, homoharringtonine and harringtonine. Furthermore, these two compounds inhibited 2'3'-cGAMP-induced IFN-stimulated gene expression and interaction between STING and TBK1. These suppressive effects were not observed with cephalotaxine devoid of the ester side-chain. Our data support the potential utility of homoharringtonine and harringtonine to treat STING-associated interferonopathy and autoimmune diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | INNATE IMMUNE-RESPONSE | - |
dc.subject | INFLAMMATORY DISEASE | - |
dc.subject | SELF-DNA | - |
dc.subject | HOMOHARRINGTONINE | - |
dc.subject | CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | KOREANA | - |
dc.subject | SENSOR | - |
dc.title | Ester alkaloids from Cephalotaxus interfere with the 2'3'-cGAMP-induced type I interferon pathway in vitro | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000406853600152 | - |
dc.identifier.doi | 10.1371/journal.pone.0182701 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.12, no.8 | - |
dc.identifier.scopusid | 2-s2.0-85026759562 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Park, Gayoung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | INFLAMMATORY DISEASE | - |
dc.subject.keywordPlus | SELF-DNA | - |
dc.subject.keywordPlus | HOMOHARRINGTONINE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KOREANA | - |
dc.subject.keywordPlus | SENSOR | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.