1,2,3,4,6-Penta-O-galloyl-beta-D-glucose, a bioactive compound in Elaeocarpus sylvestris extract, inhibits varicella-zoster virus replication
DC Field | Value | Language |
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dc.contributor.author | Bae, Sohee | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Do, Moon Ho | - |
dc.contributor.author | Lee, Chan Hee | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.date.available | 2020-02-27T17:43:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0166-3542 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5845 | - |
dc.description.abstract | The aim of this study was to establish the effect of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) on varicella-zoster virus (VZV) replication and identify the specific bioactive component(s) underlying its activity. ESE induced a significant reduction in replication of the clinical strain of VZV. Activity-guided fractionation indicated that the ethyl acetate (EtOAc) fraction of ESE contains the active compound(s) inhibiting VZV replication. High-Performance Liquid Chromatography coupled to Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-TOF-MS/MS) analysis of the EtOAc fraction of ESE facilitated the identification of 13 chemical components. Among these, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) markedly suppressed VZV-induced c-Jun N-terminal kinase (JNK) activation, expression of viral immediate-early 62 (IE62) protein and VZV replication. Our results collectively support the utility of PGG as a potential candidate anti-viral drug to treat VZV-associated diseases. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | ANTIVIRAL RESEARCH | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | HUMAN CYTOMEGALOVIRUS | - |
dc.subject | PHENOLIC-COMPOUNDS | - |
dc.subject | MASS-SPECTROMETRY | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | GENETIC-ANALYSIS | - |
dc.subject | IN-VITRO | - |
dc.subject | CELLS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | IDENTIFICATION | - |
dc.title | 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose, a bioactive compound in Elaeocarpus sylvestris extract, inhibits varicella-zoster virus replication | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000407413200026 | - |
dc.identifier.doi | 10.1016/j.antiviral.2017.06.018 | - |
dc.identifier.bibliographicCitation | ANTIVIRAL RESEARCH, v.144, pp.266 - 272 | - |
dc.identifier.scopusid | 2-s2.0-85021422995 | - |
dc.citation.endPage | 272 | - |
dc.citation.startPage | 266 | - |
dc.citation.title | ANTIVIRAL RESEARCH | - |
dc.citation.volume | 144 | - |
dc.contributor.affiliatedAuthor | Bae, Sohee | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.contributor.affiliatedAuthor | Do, Moon Ho | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Varicella zoster virus | - |
dc.subject.keywordAuthor | Antiviral | - |
dc.subject.keywordAuthor | 1,2,3,4,6-Penta-O-galloy1-beta-D-glucose | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | HUMAN CYTOMEGALOVIRUS | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | GENETIC-ANALYSIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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