Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen Xuan Nhiem | - |
dc.contributor.author | Nguyen Trung Tuong | - |
dc.contributor.author | Pham Thanh Ky | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Park, Seon Ju | - |
dc.contributor.author | Tran Minh Ngoc | - |
dc.contributor.author | Pham Hai Yen | - |
dc.contributor.author | Bui Huu Tai | - |
dc.contributor.author | Tran Hong Quang | - |
dc.contributor.author | Phan Van Kiem | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.date.available | 2020-02-27T17:44:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1612-1872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5851 | - |
dc.description.abstract | Phaeanthus vietnamensis Ban is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8R)-9,9-epoxy-3,5,3,5-tetramethoxylignan-4,4,7-triol (1), 8-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P.vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 +/- 1.2m. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3m. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMISTRY & BIODIVERSITY | - |
dc.subject | LIGNANS | - |
dc.title | Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000407608400004 | - |
dc.identifier.doi | 10.1002/cbdv.201700013 | - |
dc.identifier.bibliographicCitation | CHEMISTRY & BIODIVERSITY, v.14, no.8 | - |
dc.identifier.scopusid | 2-s2.0-85023623097 | - |
dc.citation.title | CHEMISTRY & BIODIVERSITY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Phaeanthus vietnamensis | - |
dc.subject.keywordAuthor | Annonaceae | - |
dc.subject.keywordAuthor | Sesquiterpene | - |
dc.subject.keywordAuthor | Lignan | - |
dc.subject.keywordAuthor | Aromandendrane | - |
dc.subject.keywordAuthor | Anti-inflammatory activities | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.