Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis
- Authors
- Lee, Joon-Hyop; Hwang, Yunji; Song, Ra-Yeong; Yi, Jin Wook; Yu, Hyeong Won; Kim, Su-jin; Chai, Young Jun; Choi, June Young; Lee, Kyu Eun; Park, Sue K.
- Issue Date
- Aug-2017
- Publisher
- WILEY
- Keywords
- case-control; exposure; iodine; meta-analysis; papillary thyroid carcinoma
- Citation
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.39, no.8, pp.1711 - 1718
- Journal Title
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Volume
- 39
- Number
- 8
- Start Page
- 1711
- End Page
- 1718
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5881
- DOI
- 10.1002/hed.24797
- ISSN
- 1043-3074
- Abstract
- Background: Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta-analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence. Methods: We searched MEDLINE, Embase, and the Cochrane Library for case-control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups. Results: From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054-1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389-3.483). Conclusion: This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.
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