An ultra-sensitive biophysical risk assessment of light effect on skin cells
DC Field | Value | Language |
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dc.contributor.author | Bennet, Devasier | - |
dc.contributor.author | Viswanath, Buddolla | - |
dc.contributor.author | Kim, Sanghyo | - |
dc.contributor.author | An, Jeong Ho | - |
dc.date.available | 2020-02-27T17:44:50Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07-18 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5915 | - |
dc.description.abstract | The aim of this study was to analyze photo-dynamic and photo-pathology changes of different color light radiations on human adult skin cells. We used a real-time biophysical and biomechanics monitoring system for light-induced cellular changes in an in vitro model to find mechanisms of the initial and continuous degenerative process. Cells were exposed to intermittent, mild and intense (1-180 min) light with On/Off cycles, using blue, green, red and white light. Cellular ultrastructural changes, damages, and ECM impair function were evaluated by up/downregulation of biophysical, biomechanical and biochemical properties. All cells exposed to different color light radiation showed significant changes in a time-dependent manner. Particularly, cell growth, stiffness, roughness, cytoskeletal integrity and ECM proteins of the human dermal fibroblasts-adult (HDF-a) cells showed highest alteration, followed by human epidermal keratinocytes-adult (HEK-a) cells and human epidermal melanocytes-adult (HEM-a) cells. Such changes might impede the normal cellular functions. Overall, the obtained results identify a new insight that may contribute to premature aging, and causes it to look aged in younger people. Moreover, these results advance our understanding of the different color light-induced degenerative process and help the development of new therapeutic strategies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.subject | VISIBLE-LIGHT | - |
dc.subject | ULTRAVIOLET-LIGHT | - |
dc.subject | IN-VITRO | - |
dc.subject | IRRADIATION | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPOSURE | - |
dc.subject | MELANOMA | - |
dc.subject | DAMAGE | - |
dc.subject | METALLOPROTEINASES | - |
dc.subject | SUNBURN | - |
dc.title | An ultra-sensitive biophysical risk assessment of light effect on skin cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000405694000095 | - |
dc.identifier.doi | 10.18632/oncotarget.18136 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.29, pp.47861 - 47875 | - |
dc.identifier.scopusid | 2-s2.0-85024362399 | - |
dc.citation.endPage | 47875 | - |
dc.citation.startPage | 47861 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 29 | - |
dc.contributor.affiliatedAuthor | Bennet, Devasier | - |
dc.contributor.affiliatedAuthor | Viswanath, Buddolla | - |
dc.contributor.affiliatedAuthor | Kim, Sanghyo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | biophysics of organization | - |
dc.subject.keywordAuthor | biomechanical changes | - |
dc.subject.keywordAuthor | color light radiation | - |
dc.subject.keywordAuthor | extracellular matrix degeneration | - |
dc.subject.keywordAuthor | AFM and ECIS based analysis | - |
dc.subject.keywordPlus | VISIBLE-LIGHT | - |
dc.subject.keywordPlus | ULTRAVIOLET-LIGHT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | METALLOPROTEINASES | - |
dc.subject.keywordPlus | SUNBURN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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