Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Taejung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Ham, Jungyeob | - |
dc.contributor.author | Jang, Tae Su | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.date.available | 2020-02-27T17:44:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5918 | - |
dc.description.abstract | Guggulsterone derivatives were prepared using [3+2] click chemistry with aryl and alkyl acetylene. The series of derivatives were evaluated for their cellular protective effects on cisplatin-treated cultured LLC-PK1 kidney epithelial cells. Among the guggulsterone-triazole derivatives, compound 6g, which contains a hydroxyl methyl group, was the most active of all the derivatives. In an additional study, we determined that inhibition of the mitogen-activated protein kinase/caspase-3 signaling cascade by 6g mediates its protective effects against cytotoxicity in cultured LLC-PK1 cells. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | NATURAL PRODUCT | - |
dc.subject | IN-VITRO | - |
dc.subject | ANTAGONIST | - |
dc.subject | DISEASE | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | CONSTITUENT | - |
dc.subject | ACTIVATION | - |
dc.subject | GINSENG | - |
dc.title | Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000404422000024 | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.05.033 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.14, pp.3156 - 3161 | - |
dc.identifier.scopusid | 2-s2.0-85019871777 | - |
dc.citation.endPage | 3161 | - |
dc.citation.startPage | 3156 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 27 | - |
dc.citation.number | 14 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Guggulsterone | - |
dc.subject.keywordAuthor | Kidney protection | - |
dc.subject.keywordAuthor | Click chemistry | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NATURAL PRODUCT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CONSTITUENT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GINSENG | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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