Advanced carbon dots via plasma-induced surface functionalization for fluorescent and bio-medical applications
- Authors
- Park, So Young; Lee, Che Yoon; An, Ha-Rim; Kim, Hyeran; Lee, Young-Chul; Park, Edmond Changkyun; Chun, Hang-Suk; Yang, Hee Young; Choi, Sae-Hae; Kim, Hee Sik; Kang, Kyoung Suk; Park, Hyun Gyu; Kim, Jong-Pil; Choi, Yunju; Lee, Jouhahn; Lee, Hyun Uk
- Issue Date
- 14-Jul-2017
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NANOSCALE, v.9, no.26, pp.9210 - 9217
- Journal Title
- NANOSCALE
- Volume
- 9
- Number
- 26
- Start Page
- 9210
- End Page
- 9217
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5920
- DOI
- 10.1039/c7nr03026f
- ISSN
- 2040-3364
- Abstract
- Multifunctional carbon-based nanodots (C-dots) are synthesized using atmospheric plasma treatments involving reactive gases (oxygen and nitrogen). Surface design was achieved through one-step plasma treatment of C-dots (AC-paints) from polyethylene glycol used as a precursor. These AC-paints show high fluorescence, low cytotoxicity and excellent cellular imaging capability. They exhibit bright fluorescence with a quantum yield twice of traditional C-dots. The cytotoxicity of AC-paints was tested on BEAS2B, THLE2, A549 and hep3B cell lines. The in vivo experiments further demonstrated the bio-compatibility of AC-paints using zebrafish as a model, and imaging tests demonstrated that the AC-paints can be used as bio-labels (at a concentration of < 5 mg mL(-1)). Particularly, the oxygen plasma-treated AC-paints (AC-paints-O) show antibacterial effects due to increased levels of reactive oxygen species (ROS) in AC-paints (at a concentration of > 1 mg mL(-1)). AC-paints can effectively inhibit the growth of Escherichia coli (E. coli) and Acinetobacter baumannii (A. baumannii). Such remarkable performance of the AC-paints has important applications in the biomedical field and environmental systems.
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