The clinicopathological relevance of pretransplant anti-angiotensin II type 1 receptor antibodies in renal transplantation
DC Field | Value | Language |
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dc.contributor.author | Lee, Juhan | - |
dc.contributor.author | Huh, Kyu Ha | - |
dc.contributor.author | Park, Yongjung | - |
dc.contributor.author | Park, Borae G. | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Jeong, Jong Cheol | - |
dc.contributor.author | Lee, Joongyup | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Cho, Jang-Hee | - |
dc.contributor.author | Lee, Sik | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Han, Seung-Yeup | - |
dc.contributor.author | Kim, Myoung Soo | - |
dc.contributor.author | Kim, Yu Seun | - |
dc.contributor.author | Kim, Sung Joo | - |
dc.contributor.author | Kim, Chan-Duck | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Park, Sung-Bae | - |
dc.contributor.author | Ahn, Curie | - |
dc.date.available | 2020-02-27T18:41:07Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5946 | - |
dc.description.abstract | Background: Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been suggested as a risk factor for graft failure and acute rejection (AR). However, the prevalence and clinical significance of pretransplant AT1R-Abs have seldom been evaluated in Asia. Methods: In this multicenter, observational cohort study, we tested the AT1R-Abs in pretransplant serum samples obtained from 166 kidney transplant recipients. Statistical analysis was used to set a threshold AT1R-Abs level at 9.05 U/mL. Results: Pretransplant AT1R-Abs were detected in 98/166 (59.0%) of the analyzed recipients. No graft loss or patient death was reported during the study period. AT1R-Abs (I) patients had a significantly higher incidence of biopsy-proven AR than AT1R-Abs ( ) patients (27.6 versus 10.3%, P = 0.007). Recipients with pretransplant AT1R-Abs had a 3.2-fold higher risk of AR within a year of transplantation (P = 0.006). Five study subjects developed microcirculation inflammation (score >= 2). Four of them were presensitized to AT1R-Abs. In particular, three patients had a high titer of anti-AT1R-Abs (>22.7 U/mL). Conclusions: Pretransplant AT1R-Abs is an independent risk factor for AR, especially acute cellular rejection, and is possibly associated with the risk of antibody-mediated injury. Pretransplant assessment of AT1R-Abs may be useful for stratifying immunologic risks. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.subject | ACUTE REJECTION | - |
dc.subject | MEDIATED REJECTION | - |
dc.subject | HLA ANTIBODIES | - |
dc.subject | MICROCIRCULATION INFLAMMATION | - |
dc.subject | RISK-FACTOR | - |
dc.subject | KIDNEY | - |
dc.subject | AUTOANTIBODIES | - |
dc.subject | INJURY | - |
dc.title | The clinicopathological relevance of pretransplant anti-angiotensin II type 1 receptor antibodies in renal transplantation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000405421100020 | - |
dc.identifier.doi | 10.1093/ndt/gfv375 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, v.32, no.7, pp.1244 - 1250 | - |
dc.identifier.scopusid | 2-s2.0-84996994689 | - |
dc.citation.endPage | 1250 | - |
dc.citation.startPage | 1244 | - |
dc.citation.title | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.citation.volume | 32 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Ro, Han | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | acute rejection | - |
dc.subject.keywordAuthor | angiotensin II type 1 receptor antibody | - |
dc.subject.keywordAuthor | antibody-mediated injury | - |
dc.subject.keywordAuthor | pretransplant | - |
dc.subject.keywordAuthor | renal transplantation | - |
dc.subject.keywordPlus | ACUTE REJECTION | - |
dc.subject.keywordPlus | MEDIATED REJECTION | - |
dc.subject.keywordPlus | HLA ANTIBODIES | - |
dc.subject.keywordPlus | MICROCIRCULATION INFLAMMATION | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | INJURY | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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