In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Myung Jin | - |
dc.contributor.author | Kim, Kye-Hyung | - |
dc.contributor.author | Yi, Jongyoun | - |
dc.contributor.author | Choi, Su Jin | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.available | 2020-02-27T18:41:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5949 | - |
dc.description.abstract | Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, which has been tried for treatment of SFTS. In this study, antiviral activity of ribavirin against SFTSV has been investigated. Methods: Vero cell-grown SFTSV strain Gangwon/Korea/2012 was treated with ribavirin at various concentrations. Antiviral activity of ribavirin was evaluated by inhibition of the SFTSV cytopathic effect in Vero cells and quantification of viral RNA load in culture supernatant using one-step real-time reverse transcription polymerase chain reaction. Cytotoxicity of ribavirin was determined by a tetrazolium-based colorimetric method. Results: Ribavirin reduced SFTSV titers in a dose-dependent manner, with a half-maximal inhibitory concentration ranged from 3.69 to 8.72 mu g/mL. Cytopathic effects were reduced as ribavirin concentration increased. No significant cytotoxicity was detected at ribavirin concentrations of <= 31.3 mu g/mL. Conclusions: Ribavirin exhibited inhibitory activity against SFTSV replication in vitro, which suggests that ribavirin can be used as a potential antiviral agent for SFTS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.subject | CONGO HEMORRHAGIC-FEVER | - |
dc.subject | PATHOGENESIS | - |
dc.subject | BUNYAVIRUS | - |
dc.subject | INFECTION | - |
dc.subject | THERAPY | - |
dc.subject | CHINA | - |
dc.subject | ASSAY | - |
dc.title | In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000405512900018 | - |
dc.identifier.doi | 10.3904/kjim.2016.109 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.32, no.4, pp.731 - 737 | - |
dc.identifier.kciid | ART002240950 | - |
dc.identifier.scopusid | 2-s2.0-85025151605 | - |
dc.citation.endPage | 737 | - |
dc.citation.startPage | 731 | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Myung Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Bunyaviridae infections | - |
dc.subject.keywordAuthor | Phlebovirus | - |
dc.subject.keywordAuthor | Ribavirin | - |
dc.subject.keywordAuthor | Antiviral agents | - |
dc.subject.keywordPlus | CONGO HEMORRHAGIC-FEVER | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | BUNYAVIRUS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CHINA | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.