Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Lee, Jaemin | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Lee, Hye Lim | - |
dc.contributor.author | Hahm, Dae-Hyun | - |
dc.contributor.author | Huh, Chang Ki | - |
dc.contributor.author | Lee, Sang Cheon | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T18:41:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5951 | - |
dc.description.abstract | ObjectivesMaintaining glucose homoeostasis is essential for the survival of cells. Despite the various health benefits of Korean thistle (Cirsium japonicum var. maackii), their effects on pancreatic -cell apoptosis in type 1 diabetes mellitus and the underlying mechanisms remain unclear, and experimentally investigated in this study. MethodsThe effects of C. japonicum var. maackii and its active component cirsimaritin against streptozotocin (STZ)-induced cytotoxicity were assessed in INS-1 cells. By Western blotting analysis, protein expressions related to apoptosis were evaluated. The involvement of apoptosis was also confirmed with image-based cytometric assay and caspase activity tests. Key findingsCirsium japonicum var. maackii extract and cirsimaritin in non-toxic concentrations improved cell viability to near normal levels and protected INS-1 cells against STZ-induced damage. In addition, cirsimaritin reduced the intracellular oxidative stress induced by STZ. Cirsimaritin effectively suppressed apoptosis in pancreatic cells by decreasing the activation of caspase-8 and caspase-3, BID and the DNA repair protein poly (ADP-ribose) polymerase (PARP) and increasing anti-apoptotic BCL-2 protein expression. ConclusionsThis study demonstrates the therapeutic potential and action mechanism of cirsimaritin for the prevention and treatment of type 1 diabetes mellitus. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.subject | TYPE-1 DIABETES-MELLITUS | - |
dc.subject | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | IN-VITRO | - |
dc.subject | FLAVONOIDS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | MECHANISMS | - |
dc.subject | MICE | - |
dc.subject | RATS | - |
dc.subject | SESQUITERPENES | - |
dc.title | Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000403008400009 | - |
dc.identifier.doi | 10.1111/jphp.12719 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACY AND PHARMACOLOGY, v.69, no.7, pp.875 - 883 | - |
dc.identifier.scopusid | 2-s2.0-85017416472 | - |
dc.citation.endPage | 883 | - |
dc.citation.startPage | 875 | - |
dc.citation.title | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Lee, Hye Lim | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | cirsimaritin | - |
dc.subject.keywordAuthor | Cirsium japonicum var | - |
dc.subject.keywordAuthor | maackii | - |
dc.subject.keywordAuthor | streptozotocin | - |
dc.subject.keywordPlus | TYPE-1 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | SESQUITERPENES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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