Effects of presynaptic muscarinic cholinoreceptor blockade on neuromuscular transmission as assessed by the train-of-four and the tetanic fade response to rocuronium
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong Beom | - |
dc.contributor.author | Lee, Sangseok | - |
dc.contributor.author | Lee, Kyeong Chun | - |
dc.contributor.author | Kim, Ha Jung | - |
dc.contributor.author | Ro, Young Jin | - |
dc.contributor.author | Yang, Hong-Seuk | - |
dc.date.available | 2020-02-27T18:41:17Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1440-1681 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5960 | - |
dc.description.abstract | This study investigated the effect of muscarinic M-1 and M-2 receptor antagonists on the rocuronium-induced train of four (TOF) fade and tetanic fade, respectively. Ex-vivo phrenic nerves and diaphragms were obtained from adult Sprague-Dawley rats and stabilized in Krebs buffer; the nerve-stimulated muscle TOF fade was observed at 20s intervals. For the TOF study, phrenic nerves and diaphragms were incubated with pirenzepine (an M-1 blocker) at concentrations of 0nmolL(-1) (control), 10nmolL(-1) (PZP10), or 100nmolL(-1) (PZP100). Rocuronium was then administered incrementally until the first twitch tension had depressed by >95% during TOF stimulation. The mean TOF ratios were compared when the first twitch tensions were depressed by 40%-50%. For the tetanic fade study, 50Hz/5s tetani was applied initially, 30min after the administration of a loading dose of rocuronium and methoctramine (an M-2 receptor blocker, loaded at 0molL(-1) [control], 1molL(-1) [MET1], or 10molL(-1) [MET10]). The EC95 of rocuronium was significantly lower in the PZP10 group than in the control group. In the PZP10 group, the TOF ratios at 50% and first twitch tension depression were significantly lower than those in the control group (P=.02). During tetanic stimulation, the tetanic fade was significantly enhanced in the MET10 group compared to the other groups. This study shows that antagonists of muscarinic M-1 and M-2 receptors affect the rocuronium-induced neuromuscular block as demonstrated by the reduced EC95 and TOF ratios (M-1 antagonist, pirenzepine) or the enhanced 50-Hz tetanic fade (M-2 antagonist, methoctramine). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | - |
dc.subject | ACETYLCHOLINE-RELEASE MODULATION | - |
dc.subject | MOTOR-NERVE TERMINALS | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | TRANSMITTER RELEASE | - |
dc.subject | ADENOSINE RECEPTORS | - |
dc.subject | POSTTETANIC COUNT | - |
dc.subject | ACH RELEASE | - |
dc.subject | ADULT-RAT | - |
dc.subject | JUNCTION | - |
dc.subject | AUTORECEPTORS | - |
dc.title | Effects of presynaptic muscarinic cholinoreceptor blockade on neuromuscular transmission as assessed by the train-of-four and the tetanic fade response to rocuronium | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000404367200010 | - |
dc.identifier.doi | 10.1111/1440-1681.12763 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.44, no.7, pp.795 - 802 | - |
dc.identifier.scopusid | 2-s2.0-85021311170 | - |
dc.citation.endPage | 802 | - |
dc.citation.startPage | 795 | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.volume | 44 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Kyeong Chun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | acetylcholine release | - |
dc.subject.keywordAuthor | methoctramine | - |
dc.subject.keywordAuthor | muscarinic cholinoreceptor | - |
dc.subject.keywordAuthor | neuromuscular physiology | - |
dc.subject.keywordAuthor | pirenzepine | - |
dc.subject.keywordAuthor | rocuronium | - |
dc.subject.keywordPlus | ACETYLCHOLINE-RELEASE MODULATION | - |
dc.subject.keywordPlus | MOTOR-NERVE TERMINALS | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | TRANSMITTER RELEASE | - |
dc.subject.keywordPlus | ADENOSINE RECEPTORS | - |
dc.subject.keywordPlus | POSTTETANIC COUNT | - |
dc.subject.keywordPlus | ACH RELEASE | - |
dc.subject.keywordPlus | ADULT-RAT | - |
dc.subject.keywordPlus | JUNCTION | - |
dc.subject.keywordPlus | AUTORECEPTORS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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