PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
DC Field | Value | Language |
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dc.contributor.author | Chen, Gang | - |
dc.contributor.author | Kim, Yong Ho | - |
dc.contributor.author | Li, Hui | - |
dc.contributor.author | Luo, Hao | - |
dc.contributor.author | Liu, Da-Lu | - |
dc.contributor.author | Zhang, Zhi-Jun | - |
dc.contributor.author | Lay, Mark | - |
dc.contributor.author | Chang, Wonseok | - |
dc.contributor.author | Zhang, Yu-Qiu | - |
dc.contributor.author | Ji, Ru-Rong | - |
dc.date.available | 2020-02-27T18:41:26Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5972 | - |
dc.description.abstract | Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and suppresses immunity through the receptor PD-1 expressed on T cells. However, the role of PD-L1 and PD-1 in regulating pain and neuronal function is unclear. Here we report that both melanoma and normal neural tissues including dorsal root ganglion (DRG) produce PD-L1 that can potently inhibit acute and chronic pain. Intraplantar injection of PD-L1 evoked analgesia in naive mice via PD-1, whereas PD-L1 neutralization or PD-1 blockade induced mechanical allodynia. Mice lacking Pd1 (Pdcd1) exhibited thermal and mechanical hypersensitivity. PD-1 activation in DRG nociceptive neurons by PD-L1 induced phosphorylation of the tyrosine phosphatase SHP-1, inhibited sodium channels and caused hyperpolarization through activation of TREK2 K+ channels. PD-L1 also potently suppressed nociceptive neuron excitability in human DRGs. Notably, blocking PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice. Our findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE NEUROSCIENCE | - |
dc.subject | BONE CANCER PAIN | - |
dc.subject | NEUROPATHIC PAIN | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | ANTI-PD-L1 ANTIBODY | - |
dc.subject | IMMUNE CELLS | - |
dc.subject | NIVOLUMAB | - |
dc.subject | NERVE | - |
dc.subject | MELANOMA | - |
dc.subject | TUMOR | - |
dc.subject | INFLAMMATION | - |
dc.title | PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000404115100006 | - |
dc.identifier.doi | 10.1038/nn.4571 | - |
dc.identifier.bibliographicCitation | NATURE NEUROSCIENCE, v.20, no.7, pp.917 - + | - |
dc.identifier.scopusid | 2-s2.0-85021432192 | - |
dc.citation.endPage | + | - |
dc.citation.startPage | 917 | - |
dc.citation.title | NATURE NEUROSCIENCE | - |
dc.citation.volume | 20 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Yong Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BONE CANCER PAIN | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | ANTI-PD-L1 ANTIBODY | - |
dc.subject.keywordPlus | IMMUNE CELLS | - |
dc.subject.keywordPlus | NIVOLUMAB | - |
dc.subject.keywordPlus | NERVE | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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