Preparation and Characterization of Tenofovir Disoproxil-Loaded Enteric Microparticle
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Kim, Yu-Chul | - |
dc.contributor.author | Kim, Jae Yeol | - |
dc.contributor.author | Byeon, Jimi | - |
dc.contributor.author | Maeng, Han-Joo | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Min, Kyoung Ah | - |
dc.contributor.author | Jang, Dong-Jin | - |
dc.contributor.author | Cho, Kwan Hyung | - |
dc.date.available | 2020-07-02T00:36:17Z | - |
dc.date.created | 2020-05-12 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/60105 | - |
dc.description.abstract | Tenofovir disoproxil (TD) has narrow absorption site mostly in upper intestinal tract where tenofovir rapidly decomposes. The aim of this work was to prepare and evaluate tenofovir disoproxil-loaded enteric microparticles (TDEMs) for the enhanced duodenal delivery. TDEMs were composed of TD, eudragit L-100 (EL) and ethyl cellulose (EC) as release-controlling polymers. For the physicochemical characterization, TDEMs were evaluated in terms of encapsulation efficiency (EE%), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR). The dissolution test was also performed while continuously changing the medium pH. The EE% of TO in TDEMs was good and more than 90%. The EC and EL formed a physically mixed structure and maintained their respective properties in TDEMs as confirmed by SEM image and FT-IR analysis. Combination of EL and EC gave higher enteric properties to TDEMs than the single use of EL or EC. The optimized TDEM (TD/EUEC = 0.2/1/1, w/w/w ratio) yielded mean dissolution rate less than 10% in 1 h at pH 1.2, but completed dissolution with a dissolution more than 85% within 1 h at pH 6.5. Thus, the suggested TDEM would be promising enteric microparticles for the intensive delivery of TD to the duodenum. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.title | Preparation and Characterization of Tenofovir Disoproxil-Loaded Enteric Microparticle | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000528206000089 | - |
dc.identifier.doi | 10.1166/jnn.2020.17641 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.20, no.9, pp.5796 - 5799 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 5799 | - |
dc.citation.startPage | 5796 | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Maeng, Han-Joo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Tenofovir Disorpoxil | - |
dc.subject.keywordAuthor | Eudragit L-100 | - |
dc.subject.keywordAuthor | Ethyl Cellulose | - |
dc.subject.keywordAuthor | Enteric Microparticle | - |
dc.subject.keywordPlus | ANTIRETROVIRAL ACTIVITY | - |
dc.subject.keywordPlus | ETHYL CELLULOSE | - |
dc.subject.keywordPlus | FUMARATE | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | SAFETY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
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