Small molecule DTDQ exerts anti-metastatic effects in DU145 human castration-resistant prostate cancer cells via modulations of ERK, JNK, p38 and c-Myc signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Son J. | - |
dc.contributor.author | Lee S.Y. | - |
dc.date.available | 2020-07-02T00:36:51Z | - |
dc.date.created | 2020-05-12 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/60122 | - |
dc.description.abstract | Small molecule is an organic compound with low molecular mass and can be used as a drug to treat cancer cells. 6,7-dimethyl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinolin-2(1H)-one (DTDQ) is a small molecule known to have potential anti-metastatic effects in human non-small cell lung cancer cells. Prostate cancer is one of the most common cancers in men and can progress to metastatic castration-resistant prostate cancer (CRPC) which possesses resistance to androgen deprivation therapy. In this study, we investigated the anti-metastatic effects of DTDQ in DU145 human CRPC cells. The results showed that DTDQ inhibited proliferation, migration and invasion of DU145 human CRPC cells. DTDQ suppressed activities of MMP-2 and MMP-9 of DU145 human CRPC cells via transcriptional regulation. DTDQ modulates the three major mitogen-activated protein kinases (MAPKs), ERK, JNK and p38 that are intimately associated with cancer cell metastasis. DTDQ also down-regulates c-Myc transcription factor of DU145 CRPC cells. Finally, we observed anti-metastatic effects of DTDQ in PC3 human CRPC cells, indicating that repressive effects of DTDQ are not limited to DU145 human CRPC cells. These results suggest that DTDQ may be a potential candidate of an anti-metastatic drug to treat human CRPC. © 2020 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isPartOf | Bioorganic and Medicinal Chemistry Letters | - |
dc.title | Small molecule DTDQ exerts anti-metastatic effects in DU145 human castration-resistant prostate cancer cells via modulations of ERK, JNK, p38 and c-Myc signaling pathways | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000536458600013 | - |
dc.identifier.doi | 10.1016/j.bmcl.2020.127223 | - |
dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry Letters | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85084194342 | - |
dc.citation.title | Bioorganic and Medicinal Chemistry Letters | - |
dc.contributor.affiliatedAuthor | Son J. | - |
dc.contributor.affiliatedAuthor | Lee S.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | c-Myc | - |
dc.subject.keywordAuthor | Castration-resistant prostate cancer | - |
dc.subject.keywordAuthor | DTDQ | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | Matrix metalloproteinase | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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