Comparison of Volume Retention and Biocompatibility of Acellular Dermal Matrix/Hyaluronic Acid Filler to Autologous Fat Grafts in a Mouse Model
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Hun | - |
dc.contributor.author | Kim, Sun Eung | - |
dc.contributor.author | Kim, Yu Jin | - |
dc.contributor.author | Kim, Yang Woo | - |
dc.contributor.author | Cheon, Young Woo | - |
dc.date.available | 2020-07-02T04:36:51Z | - |
dc.date.created | 2020-04-14 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0364-216X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/60211 | - |
dc.description.abstract | Background Although fat grafting has become a widely used technique in aesthetic and reconstructive surgeries, resorption is still a challenge. Micronized acellular dermal matrix (ADM) has been considered as a stable, biocompatible soft tissue coverage material that can be used as a volume filler. Here, we compared the bioacceptance and sustainability of ADM hyaluronic acid (HA) filler with human fat graft in a mouse model. Methods Harvested human fat and ADM/HA filler were injected randomly on the dorsal side of mice. Thirty-two mice were analyzed over a 7-week period with respect to volume, weight and microscopic evaluations with hematoxylin and eosin (H&E), epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) staining. Results The volume and weight were maintained at 80% and 83%, respectively, in the ADM/HA filler group and 56.5% and 49.7%, respectively, in the fat-grafted group by the 7th week. There were no significant microscopic differences in inflammatory changes and granulation via H&E staining. At 1 and 2 weeks, EGF and VEGF immunostaining intensity scores were lower in the ADM/HA filler group. At 7 weeks, there were no significant differences in immunostaining intensity scores between the two groups. Conclusions During the 7-week experimental period, the ADM/HA filler showed no foreign body reaction and the proper volume was well maintained. This suggests that the ADM/HA filler can possibly be used in small amounts as an alternative to autologous fat grafts. No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | AESTHETIC PLASTIC SURGERY | - |
dc.title | Comparison of Volume Retention and Biocompatibility of Acellular Dermal Matrix/Hyaluronic Acid Filler to Autologous Fat Grafts in a Mouse Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000522575500001 | - |
dc.identifier.doi | 10.1007/s00266-020-01680-8 | - |
dc.identifier.bibliographicCitation | AESTHETIC PLASTIC SURGERY, v.44, no.3, pp.986 - 992 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85082939600 | - |
dc.citation.endPage | 992 | - |
dc.citation.startPage | 986 | - |
dc.citation.title | AESTHETIC PLASTIC SURGERY | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hun | - |
dc.contributor.affiliatedAuthor | Kim, Sun Eung | - |
dc.contributor.affiliatedAuthor | Kim, Yu Jin | - |
dc.contributor.affiliatedAuthor | Kim, Yang Woo | - |
dc.contributor.affiliatedAuthor | Cheon, Young Woo | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | Acellular dermal matrix | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Epidermal growth factor | - |
dc.subject.keywordAuthor | Quantitative evaluation | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | RECONSTRUCTION | - |
dc.subject.keywordPlus | AUGMENTATION | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | IMPLANT | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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