Comparison of the Effects of Quetiapine XR and Lithium Monotherapy on Actigraphy-Measured Circadian Parameters in Patients With Bipolar II Depression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Jeong Yeon | - |
dc.contributor.author | Choi, Jae-Won | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Hwang, Su Hwan | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.date.available | 2020-02-27T18:42:30Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0271-0749 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6056 | - |
dc.description.abstract | Purpose/Background: The aim of this study was to evaluate the effects of quetiapine XR and lithium on actigraphy-measured circadian parameters in patients with bipolar II depression. Methods/Procedures: This was an 8-week, open-label, prospective, randomized comparative study. The assessments included the 17-item Hamilton Depression Rating Scale score and actigraphic measures concerning the previous 7 days, collected at each visit (weeks 0 [baseline], 1, 2, 4, 6, and 8); the actigraphic data were analyzed with a cosinor analysis. Findings/Results: Medication, time, and the interaction between medication and time were significantly associated with acrophase for the entire group (Ps = 0.003, 0.020, and 0.042, respectively). More specifically, acrophase was significantly delayed at weeks 1 and 6 (Ps = 0.004 and 0.039, respectively) in the quetiapine XR group. The F statistics significantly increased over time for the entire group (P < 0.001), and there was a significant increase in F statistics on weeks 4 and 6 in the quetiapine XR group (Ps = 0.016 and 0.020, respectively) and on weeks 4 and 8 in the lithium group (Ps = 0.001 and 0.016, respectively). In addition, scores on the 17-item Hamilton Depression Rating Scale were significantly associated with the F statistics during 8 weeks for the entire group (P = 0.008). Implications/Conclusions: Both quetiapine XR and lithium affected several circadian parameters, including peak activity time and robustness of circadian rhythm, but exerted different effects on acrophase in patients with bipolar II depression. In particular, clinical depressive symptoms were associated with robustness of circadian rhythm during the course of the 8-week treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | SLEEP | - |
dc.subject | DISORDER | - |
dc.subject | QUALITY | - |
dc.subject | RHYTHMS | - |
dc.subject | CLOCK | - |
dc.subject | PHASE | - |
dc.title | Comparison of the Effects of Quetiapine XR and Lithium Monotherapy on Actigraphy-Measured Circadian Parameters in Patients With Bipolar II Depression | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000399563300012 | - |
dc.identifier.doi | 10.1097/JCP.0000000000000699 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, v.37, no.3, pp.351 - 354 | - |
dc.identifier.scopusid | 2-s2.0-85015821743 | - |
dc.citation.endPage | 354 | - |
dc.citation.startPage | 351 | - |
dc.citation.title | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | actigraphy | - |
dc.subject.keywordAuthor | bipolar depression | - |
dc.subject.keywordAuthor | circadian rhythm | - |
dc.subject.keywordAuthor | lithium | - |
dc.subject.keywordAuthor | quetiapine XR | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | QUALITY | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | CLOCK | - |
dc.subject.keywordPlus | PHASE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.