Synthesis of Gallic Acid Analogs as Histamine and Pro-Inflammatory Cytokine Inhibitors for Treatment of Mast Cell-Mediated Allergic Inflammation
DC Field | Value | Language |
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dc.contributor.author | Fei, Xiang | - |
dc.contributor.author | Je, In-Gyu | - |
dc.contributor.author | Shin, Tae-Yong | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.date.available | 2020-02-27T18:42:59Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6093 | - |
dc.description.abstract | Gallic acid (3,4,5-trihydroxybenzoic acid), is a natural product found in various foods and herbs that are well known as powerful antioxidants. Our previous report demonstrated that it inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression. In this report, various amide analogs of gallic acid have been synthesized by introducing different amines through carbodiimide-mediated amide coupling and Pd/C-catalyzed hydrogenation. These compounds showed a modest to high inhibitory effect on histamine release and pro-inflammatory cytokine expression. Among them, the amide bearing (S)-phenylglycine methyl ester 3d was found to be more active than natural gallic acid. Further optimization yielded several (S)- and (R)-phenylglycine analogs that inhibited histamine release in vitro. Our findings suggest that some gallamides could be used as a treatment for allergic inflammatory diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | RELEASE | - |
dc.title | Synthesis of Gallic Acid Analogs as Histamine and Pro-Inflammatory Cytokine Inhibitors for Treatment of Mast Cell-Mediated Allergic Inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000404642100045 | - |
dc.identifier.doi | 10.3390/molecules22060898 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.22, no.6 | - |
dc.identifier.scopusid | 2-s2.0-85020663606 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Fei, Xiang | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | gallic acid | - |
dc.subject.keywordAuthor | allergic inflammation | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | pro-inflammatory cytokine | - |
dc.subject.keywordPlus | RELEASE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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