A Retrospective Study Investigating Risks of Acute Respiratory Distress Syndrome and Mortality Following Human Metapneumovirus Infection in Hospitalized Adults
DC Field | Value | Language |
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dc.contributor.author | Hwang, Hyunjung | - |
dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Park, Jeong-Woong | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.contributor.author | Kyung, Sun Young | - |
dc.date.available | 2020-02-27T18:43:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 2586-6052 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6166 | - |
dc.description.abstract | Background: Human metapneumovirus (hMPV) is a relatively recently identified respiratory virus that induces respiratory symptoms similar to those of respiratory syncytial virus infection in children. The characteristics of hMPV-infected adults are unclear because few cases have been reported. Methods: We conducted a retrospective review of hospitalized adult patients with a positive multiplex real-time polymerase chain reaction assay result from 2012 to 2016 at a single tertiary referral hospital in South Korea. We analyzed clinical characteristics of the enrolled patients and divided patients into an acute respiratory distress syndrome (ARDS) group and a non-ARDS group. Results: In total, 110 adults were reviewed in this study. Their mean age was 61.4 years, and the majority (n = 105, 955%) had comorbidities or were immunocompromised. Most of the patients had pneumonia on chest X-ray (n = 88, 93.6%), 22 (20.0%) had ARDS, and 12 (10.9%) expired during hospitalization. The mortality rate for patients with ARDS was higher than that of the other patients (36.4% vs. 5.7%, P = 0.001). The risk factor for hMPV-associated ARDS was heart failure (odds ratio, 5.24; P = 0.044) and laboratory values were increased blood urea nitrogen and increased C-reactive protein. The acquisition site of infection was divided into community vs. nosocomial; 43 patients (39.1%) had a nosocomial infection. The risk factors for nosocomial infection were an immunocompromised state, malignancy and immunosuppressive treatment. Conclusions: These data suggest that hMPV is one of the important respiratory pathogens important respiratory pathogen that causes pneumonia/ARDS in elderly, immunocompromised individuals and that it may be transmitted via the nosocomial route. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CRITICAL CARE MEDICINE | - |
dc.relation.isPartOf | ACUTE AND CRITICAL CARE | - |
dc.title | A Retrospective Study Investigating Risks of Acute Respiratory Distress Syndrome and Mortality Following Human Metapneumovirus Infection in Hospitalized Adults | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.wosid | 000476994900009 | - |
dc.identifier.doi | 10.4266/kjccm.2017.00038 | - |
dc.identifier.bibliographicCitation | ACUTE AND CRITICAL CARE, v.32, no.2, pp.182 - 189 | - |
dc.identifier.kciid | ART002227563 | - |
dc.citation.endPage | 189 | - |
dc.citation.startPage | 182 | - |
dc.citation.title | ACUTE AND CRITICAL CARE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hwang, Hyunjung | - |
dc.contributor.affiliatedAuthor | Kim, Yujin | - |
dc.contributor.affiliatedAuthor | Park, Jeong-Woong | - |
dc.contributor.affiliatedAuthor | Jeong, Sung Hwan | - |
dc.contributor.affiliatedAuthor | Kyung, Sun Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | metapneumovirus | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordAuthor | nosocomial infection | - |
dc.subject.keywordAuthor | respiratory distress syndrome | - |
dc.subject.keywordAuthor | adult | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.description.journalRegisteredClass | kci | - |
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