Inverse Association between Platelet-Lymphocyte Ratio and Prognosis in Terminally Ill Cancer Patients: A Preliminary Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yoonjoo | - |
dc.contributor.author | Kim, Ye Won | - |
dc.contributor.author | Park, Dong Kyun | - |
dc.contributor.author | Hwang, In Cheol | - |
dc.date.available | 2020-02-27T18:44:00Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1096-6218 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6170 | - |
dc.description.abstract | Background: An elevated platelet-lymphocyte ratio (PLR) is an indicator for worse outcomes in cancer, but its significance at the end of life remains unclear. Objective: This study aimed to investigate the value of PLR as an independent prognostic factor in terminally ill cancer patients. Methods: This retrospective cohort study included 312 terminal cancer patients and was conducted in a palliative care unit of a tertiary cancer center. Patient demographic data, clinical information, and laboratory values, including complete blood cell count, were obtained. Survival was analyzed using the Kaplan-Meier method and log-rank test. The Cox proportional hazards model was used to identify independent prognostic factors for survival. Results: Median survival was 16 days in patients with PLR >= 200 and 9 days in patients with PLR < 200 (p = 0.008). Results of multivariate analysis showed that the following factors predicted worse survival: poor performance status (adjusted hazard ratio [aHR], 2.16; 95% confidence interval [CI], 1.50-3.09), azotemia (aHR, 1.43; 95% CI, 1.01-2.02), hypoalbuminemia (aHR, 1.55; 95% CI, 1.07-2.26), hyperbilirubinemia (aHR, 1.67; 95% CI, 1.23-2.29), elevated lactate dehydrogenase (aHR, 1.58; 95% CI, 1.11-2.26), high neutrophillymphocyte ratio (aHR, 1.49; 95% CI, 1.09-2.04), and low PLR (aHR, 1.46; 95% CI, 1.08-1.97). Conclusion: Although elevated PLR indicates worse outcomes in patients with solid tumors, decreased PLR was an independent prognostic factor for poor survival in cancer patients at the end of life. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.relation.isPartOf | JOURNAL OF PALLIATIVE MEDICINE | - |
dc.subject | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject | NASOPHARYNGEAL CARCINOMA | - |
dc.subject | PREOPERATIVE PLATELET | - |
dc.subject | ONCOLOGY-GROUP | - |
dc.subject | BREAST-CANCER | - |
dc.subject | SOLID TUMORS | - |
dc.subject | SURVIVAL | - |
dc.subject | INFLAMMATION | - |
dc.subject | METAANALYSIS | - |
dc.subject | METASTASIS | - |
dc.title | Inverse Association between Platelet-Lymphocyte Ratio and Prognosis in Terminally Ill Cancer Patients: A Preliminary Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000400572600016 | - |
dc.identifier.doi | 10.1089/jpm.2016.0338 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PALLIATIVE MEDICINE, v.20, no.5, pp.533 - 537 | - |
dc.identifier.scopusid | 2-s2.0-85018976150 | - |
dc.citation.endPage | 537 | - |
dc.citation.startPage | 533 | - |
dc.citation.title | JOURNAL OF PALLIATIVE MEDICINE | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Yoonjoo | - |
dc.contributor.affiliatedAuthor | Kim, Ye Won | - |
dc.contributor.affiliatedAuthor | Park, Dong Kyun | - |
dc.contributor.affiliatedAuthor | Hwang, In Cheol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | platelet-lymphocyte ratio | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | terminal care | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | NASOPHARYNGEAL CARCINOMA | - |
dc.subject.keywordPlus | PREOPERATIVE PLATELET | - |
dc.subject.keywordPlus | ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.