Development of Polyethylene Glycol-Conjugated Chitosan Oligosaccharide Derivative-Stabilized Gold Nanoassemblies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hyun-Jong | - |
dc.contributor.author | Termsarasab, Ubonvan | - |
dc.contributor.author | Lee, Song Yi | - |
dc.contributor.author | Maeng, Han-Joo | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.contributor.author | Yoon, In-Soo | - |
dc.date.available | 2020-02-27T19:41:20Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6247 | - |
dc.description.abstract | Gold nanoassemblies (AuNAs) stabilized by chitosan oligosaccharide (CSO), chitosan oligosaccharide-arachidic acid (CSOAA), and chitosan oligosaccharide-arachidic acid-polyethylene glycol (CSOAA-PEG) were fabricated and evaluated. CSOAA was synthesized by amide bond formation between CSO and arachidic acid (AA), and CSOAA-PEG was then prepared by amide bond formation between CSOAA and methoxypolyethylene glycol succinimidyl succinate (mPEGSS). All AuNAs, such as CSO-stabilized AuNA (C/AuNA), CSOAA-stabilized AuNA (CA/AuNA), and CSOAA-PEG-stabilized AuNA (CAPE/AuNA), exhibited < 150 nm hydrodynamic size in the aqueous environment. Unlike C/AuNA and CA/AuNA groups, CAPE/AuNA exhibited similar particle size in aqueous buffer and serum conditions as well as in water. The results of surface plasmon resonance (SPR) measurement provided corresponded particle size of all AuNA groups, which determined by an electrophoretic light scattering (ELS) method. Developed AuNAs also did not show serious cytotoxicity in A549 (human lung adenocarcinoma) and U87-MG (human glioblastoma) cells within tested Au concentration range. Conclusively, CAPE can be used for the fabrication of hybrid AuNAs which are stable in the blood stream. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.title | Development of Polyethylene Glycol-Conjugated Chitosan Oligosaccharide Derivative-Stabilized Gold Nanoassemblies | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000397853900020 | - |
dc.identifier.doi | 10.1166/jnn.2017.13319 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.17, no.4, pp.2370 - 2373 | - |
dc.identifier.scopusid | 2-s2.0-85013371889 | - |
dc.citation.endPage | 2373 | - |
dc.citation.startPage | 2370 | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Maeng, Han-Joo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chitosan Oligosaccharide | - |
dc.subject.keywordAuthor | Gold Nanoassemblies | - |
dc.subject.keywordAuthor | Polyethylene Glycol | - |
dc.subject.keywordAuthor | Stability | - |
dc.subject.keywordPlus | ANTICANCER DRUG-DELIVERY | - |
dc.subject.keywordPlus | ARACHIDYL CHITOSAN | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.