Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax ginseng
DC Field | Value | Language |
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dc.contributor.author | Park, Hye-Jin | - |
dc.date.available | 2020-02-27T19:41:39Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6272 | - |
dc.description.abstract | Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional medicine owing to their many biological activities, including anti-inflammatory and anti-allergic activities. Previously, our group produced PL that was grown on PG media (PGP) to enhance anti-cancer activities of PGP. Here we studied the anti-allergic activity of PGP and its mechanism of action. The ethyl acetate fraction of PGP exhibited the anti-allergic activity by suppressing beta-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin E (IgE)-stimulated RBL-2H3 cells. Exposure to PGP inhibited the level of antigen/IgE-induced TNF-alpha in RBL-2H3 cells. It markedly suppressed the phosphorylation of spleen associated tyrosine kinase, GRB2-associated-binding protein 2 (Gab2) and extracellular signal-regulated kinases proteins, which are required for the degranulation and production of pro-inflammatory cytokines. Its anti-inflammatory activity was observed in lipopolysaccharide-stimulated RAW 264.7 cells. In addition, PGP contained higher contents of Rg1 than PG. Our findings suggest that PGP might be developed as a therapeutic agent for IgE-mediated allergic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | INHIBITS INFLAMMATORY MEDIATORS | - |
dc.subject | ETHYL-ACETATE EXTRACT | - |
dc.subject | MAST-CELLS | - |
dc.subject | ALLERGIC RESPONSES | - |
dc.subject | ACTIVATION | - |
dc.subject | MICE | - |
dc.subject | ANAPHYLAXIS | - |
dc.subject | MACROPHAGES | - |
dc.subject | AGENTS | - |
dc.title | Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax ginseng | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000399818200024 | - |
dc.identifier.doi | 10.1007/s10068-017-0064-8 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.26, no.2, pp.467 - 472 | - |
dc.identifier.kciid | ART002216879 | - |
dc.identifier.scopusid | 2-s2.0-85018512261 | - |
dc.citation.endPage | 472 | - |
dc.citation.startPage | 467 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | PGP | - |
dc.subject.keywordAuthor | anti-allergic activity | - |
dc.subject.keywordAuthor | anti-inflammatory activity | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INHIBITS INFLAMMATORY MEDIATORS | - |
dc.subject.keywordPlus | ETHYL-ACETATE EXTRACT | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | ALLERGIC RESPONSES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ANAPHYLAXIS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | AGENTS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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