Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis
DC Field | Value | Language |
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dc.contributor.author | Wu, Chia-Shan | - |
dc.contributor.author | Bongmba, Odelia Y. N. | - |
dc.contributor.author | Yue, Jing | - |
dc.contributor.author | Lee, Jong Han | - |
dc.contributor.author | Lin, Ligen | - |
dc.contributor.author | Saito, Kenji | - |
dc.contributor.author | Pradhan, Geetali | - |
dc.contributor.author | Li, De-Pei | - |
dc.contributor.author | Pan, Hui-Lin | - |
dc.contributor.author | Xu, Allison | - |
dc.contributor.author | Guo, Shaodong | - |
dc.contributor.author | Xu, Yong | - |
dc.contributor.author | Sun, Yuxiang | - |
dc.date.available | 2020-02-27T19:41:54Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6289 | - |
dc.description.abstract | Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis. To further decipher the specific neuronal circuits mediating the metabolic effects of GHS-R, we generated AgRP neuron-specific GHS-R knockout mice (AgRP-Cre;Ghsr(f/f)). Our data showed that GHS-R in AgRP neurons is required for ghrelin's stimulatory effects on growth hormone secretion, acute food intake and adiposity, but not for long-term total food intake. Importantly, deletion of GHS-R in AgRP neurons attenuated diet-induced obesity (DIO) and enhanced cold-resistance in mice fed high fat diet (HFD). The HFD-fed knockout mice showed increased energy expenditure, and exhibited enhanced thermogenic activation in both brown and subcutaneous fat; this implies that GHS-R suppression in AgRP neurons enhances sympathetic outflow. In summary, our results suggest that AgRP neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP neurons plays crucial roles in governing energy utilization and pathogenesis of DIO. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | GROWTH-HORMONE SECRETAGOGUE | - |
dc.subject | BROWN ADIPOSE-TISSUE | - |
dc.subject | CAUSES GHRELIN RESISTANCE | - |
dc.subject | ENERGY-BALANCE | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | NPY/AGRP NEURONS | - |
dc.subject | ADAPTIVE THERMOGENESIS | - |
dc.subject | MITOCHONDRIAL DYNAMICS | - |
dc.subject | HYPOTHALAMIC NEURONS | - |
dc.subject | OREXIGENIC ACTION | - |
dc.title | Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000402639400156 | - |
dc.identifier.doi | 10.3390/ijms18040832 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.18, no.4 | - |
dc.identifier.scopusid | 2-s2.0-85018525713 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Jong Han | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Agouti-related peptide (AgRP) | - |
dc.subject.keywordAuthor | ghrelin | - |
dc.subject.keywordAuthor | growth hormone secretagogue receptor (GHS-R) | - |
dc.subject.keywordAuthor | diet-induced obesity (DIO) | - |
dc.subject.keywordAuthor | thermogenesis | - |
dc.subject.keywordPlus | GROWTH-HORMONE SECRETAGOGUE | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | CAUSES GHRELIN RESISTANCE | - |
dc.subject.keywordPlus | ENERGY-BALANCE | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | NPY/AGRP NEURONS | - |
dc.subject.keywordPlus | ADAPTIVE THERMOGENESIS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYNAMICS | - |
dc.subject.keywordPlus | HYPOTHALAMIC NEURONS | - |
dc.subject.keywordPlus | OREXIGENIC ACTION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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