A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2-early breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gong, Gyungyub | - |
dc.contributor.author | Kwon, Mi Jeong | - |
dc.contributor.author | Han, Jinil | - |
dc.contributor.author | Lee, Hee Jin | - |
dc.contributor.author | Lee, Se Kyung | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Lee, Seon-Heui | - |
dc.contributor.author | Park, Sarah | - |
dc.contributor.author | Choi, Jong-Sun | - |
dc.contributor.author | Cho, Soo Youn | - |
dc.contributor.author | Ahn, Sei Hyun | - |
dc.contributor.author | Lee, Jong Won | - |
dc.contributor.author | Cho, Sang Rae | - |
dc.contributor.author | Moon, Youngho | - |
dc.contributor.author | Nam, Byung-Ho | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Shin, Young Kee | - |
dc.date.available | 2020-02-27T19:42:08Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-03-28 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6303 | - |
dc.description.abstract | To make an optimal treatment decision for early stage breast cancer, it is important to identify risk of recurrence. Here, we developed and validated a new prognostic model for predicting the risk of distant metastasis in patients with pN0-N1, hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer treated with hormone therapy alone. RNA was extracted from formalin-fixed, paraffin-embedded tumor tissues and gene expression was measured by quantitative realtime reverse transcription-PCR. The relative expression of six novel prognostic genes was combined with two clinical variables (nodal status and tumor size) to calculate a risk score (BCT score). In the validation cohort treated with hormone therapy alone, the 10 year rate of distant metastasis in the high-risk group (26.3%) according to BCT score was significantly higher than that in the low-risk group (3.8%) (P < 0.001). Multivariate analysis adjusted for clinical variables revealed that BCT score is an independent predictor of distant metastasis. Moreover, the C-index estimate revealed that BCT score has a prognostic power superior to that of prognostic models based on clinicopathological parameters. The BCT score outperforms prognostic models based on traditional clinicopathological factors and predicts the risk of distant metastasis in patients with HR+/HER2- early breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | INTERNATIONAL EXPERT CONSENSUS | - |
dc.subject | 21-GENE RECURRENCE SCORE | - |
dc.subject | ESTROGEN-RECEPTOR | - |
dc.subject | PRIMARY THERAPY | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | BASAL-LIKE | - |
dc.subject | EXPRESSION | - |
dc.subject | TAMOXIFEN | - |
dc.subject | IMMUNOHISTOCHEMISTRY | - |
dc.subject | VALIDATION | - |
dc.title | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2-early breast cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000397542700001 | - |
dc.identifier.doi | 10.1038/srep45554 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.identifier.scopusid | 2-s2.0-85016394933 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Lee, Seon-Heui | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTERNATIONAL EXPERT CONSENSUS | - |
dc.subject.keywordPlus | 21-GENE RECURRENCE SCORE | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | PRIMARY THERAPY | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | BASAL-LIKE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TAMOXIFEN | - |
dc.subject.keywordPlus | IMMUNOHISTOCHEMISTRY | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.